EXPRESSION FEATURES OF IL‑28B IN CHILDREN WITH ASTHMA

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Abstract

In the present study, an important antiviral cytokine IL-28B was studied at the level of gene expression and molecule production in the mucosa of the nasal cavity in patients with asthma of varying severity. In children with mild asthma, an increase in gene expression was consistent with an increase in IL-28B production. At the same time, patients with severe asthma had a reverse dependence of a significant increase in gene expression led to a decrease in IL-28B synthesis. There was a significant increase in the content of proinflammatory cytokines IL-1β, IL-6 and TNFα in nasal lavage in patients with severe asthma. Imbalance in the local level of cytokines in the nasal mucosa, accompanied by an increase in the production of proinflammatory cytokines and a decrease in the antiviral cytokine IL-28B. It may be important pathogenetic link of both the formation of asthma itself and its virus-induced complications.

About the authors

L. V. Gankovskaya

Russian National N. Pirogov Research Medical University

Author for correspondence.
Email: lvgan@yandex.ru

PhD, MD (Medicine), Professor, Head, Department of Immunology, Medicobiologic Faculty

123557 Moscow, Zoological pereulok, 8, 100

Russian Federation

L. S. Namazova‑Baranova

National Scientific and Practical Center of Children’s Health

Email: fake@neicon.ru

PhD, MD (Medicine), Professor, Full Member, Russian Academy of Sciences, Head, Department of Pediatrics No. 1, Russian National N. Pirogov Research Medical University; Deputy-director on Science, National Scientific and Practical Center of Children’s Health

Moscow Russian Federation

O. A. Svitich

Russian National N. Pirogov Research Medical University

Email: fake@neicon.ru

PhD, MD (Medicine), Corresponding Member, Russian Academy of Sciences, Professor, Department of Immunology, Medicobiologic Faculty

Moscow

Russian Federation

B. G. Bragvadze

Russian National N. Pirogov Research Medical University

Email: fake@neicon.ru

Postgraduate Student, Department of Immunology, Medicobiologic Faculty

Moscow

Russian Federation

A. A. Alekseeva

National Scientific and Practical Center of Children’s Health

Email: fake@neicon.ru

PhD (Medicine), Department of Pediatrics No. 1, Russian National N. Pirogov Research Medical University; Head of the Department of rehabilitation of children with allergic diseases and respiratory diseases, National Scientific and Practical Center of Children’s Health

Moscow

Russian Federation

V. A. Gankovskii

National Scientific and Practical Center of Children’s Health

Email: fake@neicon.ru

PhD (Medicine), The ENT specialist of the Department of rehabilitation treatment of children with diseases of ENT organs and oral and maxillofacial region

Moscow

Russian Federation

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Copyright (c) 2017 Gankovskaya L.V., Namazova‑Baranova L.S., Svitich O.A., Bragvadze B.G., Alekseeva A.A., Gankovskii V.A.

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