PERSONAL IMMUNOLOGICAL PHENOTYPE AND BREAST CANCER RISK IN POSTMENOPAUSAL WOMEN

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Abstract

The following immunological phenotypes were described using immunoanalysis of blood serum IgABp, IgA-Es and IgA-Pg in 400 healthy women and 1284 breast cancer (BC) patients: “protective” with the minimal BC risk (OR=0.2–0.6) in which personal IgA-Pg level exceeded both IgA-Bp and IgA-Es; “procarcinogenic” with maximal BC risk (OR=2.1–6.2) in which both IgA-Bp and IgA-Es were higher than IgA-Pg; and two “compensatory” (OR=0.7–1.2) in which IgA-Pg levels exceeded IgA-Bp or IgAEs. Existence of one or the other immunophenotype did not depended from smocking or age. The diff erences in correlations of IgA-Bp with IgA-Es and IgA-Pg were revealed at these immunophenotypes. The results would be helpful in the creation and clinical application of anticarcinogenic vaccines for cancer immunoprevention.

About the authors

A. N. Glushkov

Institute of Human Ecology, Federal Research Center of Coal and Coal Chemistry SB RAS

Author for correspondence.
Email: stellamun@yandex.ru

MD, Professor, Chief Researcher of Immunogenetics Laboratory,

650065, Kemerovo, Leningradsky Avenue, 10

Russian Federation

E. G. Polenok

Institute of Human Ecology, Federal Research Center of Coal and Coal Chemistry SB RAS

Email: fake@neicon.ru

PhD (Candidate of Pharmacy), Leading Researcher of Immunochemistry Laboratory,

Kemerovo

Russian Federation

S. A. Mun

Institute of Human Ecology, Federal Research Center of Coal and Coal Chemistry SB RAS

Email: fake@neicon.ru

PhD (Candidate of Medicine), Senior Researcher Fellow of Immunogenetics Laboratory,

Kemerovo

Russian Federation

L. A. Gordeeva

Institute of Human Ecology, Federal Research Center of Coal and Coal Chemistry SB RAS

Email: fake@neicon.ru

PhD (Candidate of Biology), Leading Researcher of Immunogenetics Laboratory,

Kemerovo

Russian Federation

M. V. Kostyanko

Institute of Fundamental Sciences

Email: fake@neicon.ru

Leading Engineer of the Organic Chemistry Chair,

Kemerovo

Russian Federation

A. V. Antonov

Regional Clinical Oncology Dispensary

Email: fake@neicon.ru

Deputy chief physician for surgery,

Kemerovo

Russian Federation

N. E. Verzhbitskaya

Regional Clinical Oncology Dispensary

Email: fake@neicon.ru

PhD (Candidate of Medicine), Chief of Pathoanatomy Department,

Kemerovo

Russian Federation

I. A. Vafin

Regional Center of Blood

Email: fake@neicon.ru

Main Physician,

Kemerovo

Russian Federation

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Copyright (c) 2019 Glushkov A.N., Polenok E.G., Mun S.A., Gordeeva L.A., Kostyanko M.V., Antonov A.V., Verzhbitskaya N.E., Vafin I.A.

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