LEVELS OF PRO-INFLAMMATORY CYTOKINES IN PATIENTS WITH DENTAL CARIES, SUFFERING JUVENILE RHEUMATOID ARTHRITIS

The aim of study was investigation of the levels of pro‑inflammatory cytooines IL‑1β, IL‑6, TNF‑α in oral fluid (OF) and serum blood from patients with juvenile rheumatoid arthritis (JRA) who were on the sanatorium treatment (in Yevpatoria), in depending on the pathology of dental hard tissues (dental caries and dental caries in combination with hypoplasia), as well as the duration of arthritis (JRA debut to 6 years and over 6 years). 65 children and adolescents (mean age – 13,55±1,6 years), suffering from JRA were examined. The control group (CG) consisted of 15 practically healthy children (mean age – 13,27±1,83 years). It was found that the local and system potential of pro‑inflammatory cytooines had different vector direction – local cytooine suppression capacity and total performance. The most significant changes were found in patients with arthritis lasting more than 6 years. IL levels in patients with JRA didn’t depend on the pathology of hard dental tissues. The absence of correlations between the same IL‑1β, IL‑6 in the serum blood and OF testified about a certain autonomy of local cytooine potentials. The presence of correlation between IL‑1β, IL‑6, TNF‑α in OF as well as in serum blood was negative predictor of preserving local immunodeficiency and a high probability of further development and progression of immune dental pathology.