DETERMINING THE RISK OF THROMBOEMBOLIC COMPLICATIONS IN PATIENTS AFTER CORONARY ARTERY GFAFTING ON THE BASIS OF CLUSTER ANALYSIS

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Abstract

Ishemic heart disease continues to be the most frequent cause of sluggishness, disability and economic loss in the modern industrial community. At the present time, there is an acute need to use information technologies in evaluating the biochemical processes occurring in the body in the atherosclerotic lesion of arteries in patients with coronary heart disease and as a result of the development of thromboembolic complications of various localizations (heart, brain, lungs) of diff erential diagnostics. 97 patients of both sexes with IHD before and after myocardial revascularization by CABG were examined at the age of 45 to 74 years. The control group consisted of 30 healthy volunteers, comparable in age and sex. Blood sampling was performed a day before the operation, on days 1, 3, 7 and 12 after coronary artery bypass grafting. Cluster analysis was carried out on three revealed indices (TNF-α, MMP-1 and IL-10). Cluster analysis confirmed that the most significant statistically significant changes in the level of TNF-α, IL-10, and MMP-1 were detected in the TEO group. In addition, the increase in TNF-α by 9–10 times and more (from 24 pg / ml) in the preoperative period, IL-10 is higher than 65 pg / ml before operation and from 320 pg / ml on the 1-st day after the operation and increase of MMP-1 in 3 times (from 3.3 ng / ml) before and after CABG is considered to be an additional early marker of the risk of thromboembolic complications after coronary artery bypass grafting.

About the authors

E. V. Markelova

Pacific State Medical University” of the Ministry of Health of the Russian Federation

Author for correspondence.
Email: fake@neicon.ru

MD, professor, Chair of Normal and Pathological Physiology Department,

Vladivostok

Russian Federation

E. V. Shkorik

Pacific State Medical University” of the Ministry of Health of the Russian Federation

Email: shkorikev@mail.ru

the graduate student of department of Normal and Pathological Physiology Department,

690106, Vladivostok, Ostryakova Avenue 4

Russian Federation

A. A. Silaev

FSBEI IN “Irkutsk State Medical University” Ministry of healthcare of the Russian Federation

Email: fake@neicon.ru

PhD, MD,

Irkutsk

Russian Federation

O. L. Zhdanova

FSBIS Automation and Control Processes of FEB RAS

Email: fake@neicon.ru

senior researcher, Doctor of Physico-Mathematical Sciences,

Vladivostok

Russian Federation

References

  1. Александрова Е. Б. Хроническая сердечная недостаточность у больных гипертонической болезнью и ишемической болезнью сердца: возрастные и тендерные аспекты: Кардиология 2013, 7, 40–44.
  2. Chen W., Li Z., Bai L., Lin Y. NF-kappa B in lung cancer, a carcinogenesis mediator and a prevention and therapy target. Front Biosci. 2011, 16, 1172–1185. doi: 10.2741/3782.
  3. Burton-Freeman B. Postprandial metabolic events and fruit-derived phenolics: a review of the science. Br J Nutr. 2010, 104 (Suppl 3), S1–S14. doi: 10.1017/S0007114510003909.
  4. Frangogiannis N. G. The immune system and cardiac repair. Pharmacol Res. 2008, 58, 88–111.
  5. Крукович А. А., Примак Н. В., Захарчук Н. В., Мокшина М. В. Тромбоэмболия легочной артерии: вопросы диагностики и прогноза. Тихоокеанский медицинский журнал 2017, 4, 31–37.
  6. Rao V. H., Kansal V., Stoupa S., Agrawal D. K. MMP-1 and MMP-9 regulate epidermal growth factor-dependent collagen loss in human carotid plaque smooth muscle cells: Physiol. Rep. 2014, 2, 2, e00224.
  7. Турмова Е. П., Маркелова Е. В., Силаев А. А. Особенности цитокинового статуса у больных с атеросклерозом. Медицинская иммунология 2014, 16, 4, 323–332.
  8. Осипова О. А., Власенко М. А., Годлевская О. М., Суязнова С. Б. Цитокины в развитии и прогрессировании хронической сердечной недостаточности: Вестник новых медицинских технологий 2012, 19, 2, 322–327.
  9. Шальнев В. И., Мазуров В. И. Регуляторные нарушения ИЛ-8, ИЛ-10 при остром коронарном синдроме. Вестник Санкт-Петербургской медицинской академии последипломного образования 2010, 2, 4, 65–66.
  10. Du. T., Tan Z. Relationship between deep venous thrombosis and infl ammatory cytokines in postoperative patients with malignant abdominal tumors: Braz. J. of Med. and Biol. Res. 2014, Vol. 47, 11, 1003–1007.
  11. Mаlarstig А., Eriksson Р., Hamsten А., Lindahl B., Wallentin L., Siegbahn A. Raised interleukin-10 is an indicator of poor outcome and enhanced systemic inflammation in patients with acute coronary syndrome. Heart 2008, 94, 6, 724–729.
  12. Abe R., Hirasawa H., Oda S., Sadahiro T., Nakamura M., Watanabe E., Nakada Taka-aki, Hatano M., Tokuhisa T. Up-regulation of interleukin-10 mRNA expression in peripheral leukocytes predicts poor outcome and diminished human leukocyte antigen-DR expression on monocytes in septic patients. J. Surg. Res. 2008, 147, 1, 1–8.
  13. Zotova N. V., Chereshnev V. A., Gusev E. Y. Systemic Inflammation: Methodological Approaches to Identifi cation of the Common Pathological Process. PLoS One 2016, 11, 5, e0155138.
  14. Jia P., Wu N., Zhang X., Jia D. Association of matrix metalloproteinase-1-519A / G polymorphism with acute coronary syndrome: a meta-analysis. Int. J. Clin. Exp. Med. 2015, 8, 4, 5675–5682.
  15. Ниворожкина Л. И., Арженовский С. Б. Многомерные статистические методы в экономике: Учебник. М.: Дашков и К, 2008.
  16. Силаев А. А., Турмова Е. П., Раповка В. Г. Изменение продукции цитокинов при развитии послеоперационных воспалительных осложнений у пациентов с атеросклерозом коронарных артерий: Бюллетень Восточно-Сибирского научного центра СО РАМН 2013, 1 (89), 190–193.
  17. Tamayo E., Fernandez A., Almansa R., Carrasco E., Heredia M., Lajo C., Goncalves L., Gómez-Herreras J. I., de Lejarazu R. O., Bermejo-Martin J. F. Pro- and anti-infl ammatory responses are regulated simultaneously from the first moments of septic shock. Eur. Cytokine Netw. 2011, 22, 2, 82–87. doi: 10.1684/ecn.2011.0281.

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Copyright (c) 2019 Markelova E.V., Shkorik E.V., Silaev A.A., Zhdanova O.L.

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