HYPEREMESIS GRAVIDARUM IS A CYTOKINE STORM?



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AbstractTarget. To study the systemic response of proinflammatory cytokines in women suffering from VP.Material and methods. The main group consisted of 47 women with VP, which was divided into 3 subgroups according to severity: the 1st - included 16 patients with mild VP, the 2nd - 15 - with moderate severity, and the 3rd - 16 women with severe VP. The control group consisted of 10 pregnant women with a physiological course without signs of toxicosis. Interleukins (IL-1β, IL-6, TNFα) were determined in the blood serum of pregnant women by solid-phase ELISA using Cytokine test kits (St. Petersburg, Russia).Results. With increasing severity of toxicosis, there is a significant increase in IL-1β in severe VP - 1.9 times higher than the same value of the norm (p<0.05), 2 times higher than in mild vomiting (p<0.05), and in 1.7 times – with moderate VP (p<0.05). The study of the level of IL-6 revealed a directly proportional increase in the indicator with increasing severity of toxicosis in relation to the control indicator: with mild vomiting - 1.9 times (p<0.05), with moderate vomiting - 2.6 times (p<0.001) and in severe VP – 2.9 times (p<0.0001). A significant decrease in the level of TNFα was observed with increasing severity of toxicosis in relation to the control indicator: with mild vomiting - by 1.5 times (p<0.05), with moderate vomiting - by 1.9 times (p<0.05) and with severe VP – 2.1 times (p<0.05).Conclusions. Excessive secretion of proinflammatory cytokines IL-1β and IL-6 (2 and 3 times, respectively), exceeding the norm, with a sharp suppression of TNFα production (2 times) can be considered as predictors of a “cytokine storm”, clinically occurring with multiple organ failure up to death if the pregnancy is not terminated in a timely manner.

About the authors

Yulduz Djabbarova K. Djabbarova

Tashkent Pediatric Medical Institute of Health of the Republic of Uzbekistan

Email: ulduzjab43@mail.ru
ORCID iD: 0000-0002-3456-2381

Academician of the Medical and Technical Academy of the Russian Federation,   MD, PhD, DSci (Medicine),  Professor Department of Pharmacology, Physiology of the Tashkent Pediatric Medical Institute, obstetrician-gynecologist of the Republican Perinatal Center Ministry of Health of the Republic of Uzbekistan, Tashkent, Uzbekistan. 

Uzbekistan, 223 Bogishamol str., Yunusabad district, 100140, Tashkent Pediatric Medical Institute Tashkent city Uzbekistan

Sitora Abdieva

Fergana Institute of Public Health, Fergana Uzbekistan

Email: Setoraabdullajonova@gmail.com

PhD candidate, assistant at the Department of Obstetrics and Gynecology, Fergana Institute of Public Health, Fergana Uzbekistan

Uzbekistan, Fergana Institute of Public Health, Fergana Uzbekistan

Mathiya Erkinovna Suyarkulova

Fergana Institute of Public Health, Fergana Uzbekistan

Author for correspondence.
Email: madhiya12@gmail.com

PhD,, Head of the Department of Obstetrics and Gynecology

Uzbekistan, Fergana Institute of Public Health, Fergana Uzbekistan

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