INTERRELATIONS BETWEEN IRON CONTENT AND IMMUNE DYSFUNCTIONS IN FREQUENTLY ILL CHILDREN OF THE ARAL SEA REGION
- Authors: Jiemuratova G.K.1, Aripova T.U.2, Kamalov Z.S.3, Mambetkarimov G.A.4
-
Affiliations:
- Nukus branch of the Institute of Immunology and Human Genomics of the Academy of Sciences of the Republic of Uzbekistan, Nukus, Uzbekistan
- Institute of Human Immunology and Genomics of the Academy of Sciences of the Republic of Uzbekistan, Tashkent, Uzbekistan
- Institute of Human Immunology and Genomics of the Academy of Sciences of the Republic of Uzbekistan, Tashkent, Uzbekistan.
- Karakalpak Branch of the Republican Scientific Center of Emergency Medical Care, Nukus, Uzbekistan
- Section: Joint Immunology Forum 2024
- URL: https://rusimmun.ru/jour/article/view/16661
- DOI: https://doi.org/10.46235/1028-7221-16661-IBI
- ID: 16661
Cite item
Full Text
Abstract
AbstractThe widespread occurrence of immune-dependent diseases and disturbances in iron metabolism, as well as their co-occurrence and the impact of iron deficiency on the immune system, underscore the relevance of this study. Modern data also indicate the involvement of iron in regulating cytokine production and protein synthesis by lymphocytes. In addition to the age-related characteristics of the child's immune system, a significant factor in the development of inadequate course of the infectious process is the disruption of immune system adaptation, which can be caused by frequent infections, other somatic diseases such as anemia, and environmental factors.
The aim of this study is to assess the relationship between iron levels and immune dysfunction in children with frequent acute respiratory diseases living in the Aral Sea region.
A total of 127 children, who are native residents living at the epicenter of the ecological crisis, were examined. The children's ages ranged from 1 to 5 years old. Among them, there were 105 frequently ill children (with 6 or more episodes of acute respiratory infections per year) with iron-deficiency anemia (IDA), and 22 healthy children of the same age. All children underwent clinical examination and standard laboratory tests, including complete blood count, relative content and ratio of T and B lymphocytes, as well as the levels of pro- and anti-inflammatory cytokines (IL-2 and 4) and ferritin in the serum.
According to the results of the conducted research, it was found that among frequently ill children with iron-deficiency anemia (IDA), there is a moderate positive correlation between the relative quantity of T-lymphocytes and the hemoglobin level (r=+0.62), as well as a strong positive correlation with the serum iron level (r=+0.78). This indicates a significant influence of iron deficiency on the level of cellular immunity. Clinical data also indicate a higher risk of respiratory infections development in children with IDA compared to the control group. Ferritin, hemoglobin, lymphocytes, and cytokines act as positive regulators of hematopoiesis in IDA conditions and contribute to the compensation of anemia during iron deficiency replenishment.
About the authors
Gulparshin Koshkinbayevna Jiemuratova
Nukus branch of the Institute of Immunology and Human Genomics of the Academy of Sciences of the Republic of Uzbekistan, Nukus, Uzbekistan
Email: gulparshin_76@mail.ru
ORCID iD: 0000-0002-7190-8548
Candidate of Medical Sciences, Senior Researcher
UzbekistanTamara Uktamovna Aripova
Institute of Human Immunology and Genomics of the Academy of Sciences of the Republic of Uzbekistan, Tashkent, Uzbekistan
Email: t.u.aripova@mail.ru
Doctor of Medical Sciences, Academician, Director
Uzbekistan, Ya. Gulyamova str., Tashkent, 100060Zainitdin Sayfutdinovich Kamalov
Institute of Human Immunology and Genomics of the Academy of Sciences of the Republic of Uzbekistan, Tashkent, Uzbekistan.
Email: zay_kamal@rambler.ru
Doctor of Medical Sciences, Professor, Head of the Laboratory of Immunoregulation
Uzbekistan, Address: 74 Ya. Gulyamova str., Tashkent, 100060Gairat Abdikarimovich Mambetkarimov
Karakalpak Branch of the Republican Scientific Center of Emergency Medical Care, Nukus, Uzbekistan
Author for correspondence.
Email: m.gayrat66@mail.ru
Doctor of Medical Sciences, Deputy Director for Scientific Work
Uzbekistan, Nukus, Dosnazarova street 123References
- Gаzaliyeva М.А., Аkhmetova N.Sh., Zhumabekova B.K., et al. Status of population health ecologically disadvantaged regions of Kazakhstan // Journal of medical sciences, 2016. No. 5. – P.32-39
- Zenina O.M., Kushnareva M.V., Keshishyan E. S. The phagocytic activity of blood neutrophils in children of early age for prevention of respiratory infection in the closed group. Ros vestn perinatol i pediatr 2014; 59: 5: 56–58.
- Kazyukova T.V. Iron deficiency prophylaxis in young children. Pediatriya 2011; 90: 4: 112–119.
- Mazankova L.N., Chebotareva T.A., Maikova I.D. et al. Cytokine status and efficiency of cytokine therapy of rotavirus infection in children. Farmateka 2015; 4: 297: 73–74.
- Treneva M.S., Munblit D.B.,
- Ivannikov N.Y. et al. The reference values of cytokine levels of colostrum and breast milk in the female population. Pediatria
- ; 93; 3: 41–45.
- Khanturina G.R., Seytkasymova G.Zh., Fedorova I. A. Ecological hygienic assessment of the environment of adjacent
- territories of zones of anthropogenic impact. Gigiena i Sanitaria (Hygiene and Sanitation, Russian journal) 2017; 96(3): 222-226. (In Russ.).
- DOI: http://dx.doi.org/ 10.18821/0016-9900-2017-96-3-222-226
- Khaitov R.M., Pinegin B.V., Pashenkov M.V. Epithelial cells of the respiratory tract as equal participants of innate immunity and potential targets for immunotropic drugs. Immunologiya.2020; 41 (2): 107–13. doi: 10.33029/0206-4952-2020-41-2-107-113 (in Russian)
- Cronin S.J.F., Woolf C.J., Weiss G., Penninger J.M. The Role of Iron Regulation in Immunometabolism and Immune-Related Disease. // Front. Mol. Biosci. – 2019; 6: 116. doi: 10.3389/fmolb.2019.00116.
- Hassan T.H., Badr M.A., Karam N.A. et al. Impact of
- iron defi ciency anemia on the function of the immune system in
- children. // Medicine (Baltimore). – 2016; 95(47): e5395. DOI:
- 1097/MD.0000000000005395.
- Vimercati L., Gatti M.F., Baldassarre A., Nettis E., Favia N., Palma M, Martina GL, Di Leo E, Musti M. Occupational Exposure to Urban Air Pollution and Allergic Diseases // Int J Environ Res Public Health. 2015. Vol. 12. N 10. P.12977–12987. doi: 10.3390/ijerph121012977 www. ncbi.nlm.nih.gov/ pmc/articles/PMC4627011