PLEIOTROPICITY OF IMMUNOMODULATING EFFECTS OF SYNTHETIC THYMIC HEXAPEPTIDE IN CHRONIC INFECTIOUS AND INFLAMMATORY DISEASES OF THE GENITAL TRACT IN IMMUNOCOMPROMIZED WOMEN

Irina Vadimovna Nesterova; Нестерова Ирина Вадимовна; Svetlana Valentinovna Kovaleva; Ковалева Светлана Валентиновна; Svetlana Nikolayevna Pikturno; Пиктурно Cветлана Николаевна; Аlla Mihaylovna Chulkova; Чулкова Алла Михайловна; Nelli Noevna Kuranova; Куранова Нелли Ноевна; Anna Ivanovna Pirogova; Пирогова Анна Ивановна; Elisey Andreyevich Poezzhaev; Поезжаев Елисей Андреевич

doi:10.46235/1028-7221-16740-POI

PLEIOTROPICITY OF IMMUNOMODULATING EFFECTS OF SYNTHETIC THYMIC HEXAPEPTIDE IN CHRONIC INFECTIOUS AND INFLAMMATORY DISEASES OF THE GENITAL TRACT IN IMMUNOCOMPROMIZED WOMEN

Authors: Nesterova I.V.¹^,2, Kovaleva S.V.¹, Pikturno S.N.¹, Chulkova А.M.¹, Kuranova N.N.¹, Pirogova A.I.¹, Poezzhaev E.A.¹
Affiliations:
1. Federal State Budgetary Institution of Higher Professional Education «Kuban State Medical University» of the Ministry of Healthcare of the Russian Federation, Krasnodar, Russian Federation
2. Peoples' Friendship University of Russia named after Patrice Lumumba, Moscow, Russian Federation
Section: Joint Immunology Forum 2024
URL: https://rusimmun.ru/jour/article/view/16740
DOI: https://doi.org/10.46235/1028-7221-16740-POI
ID: 16740

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Abstract

AbstractA reason for the protracted course and frequent recurrence of pelvic inflammatory diseases (PID) is dysfunction of the immune system, which dictates the need of effective immunotherapeutic approaches. Objective: to clarify the features of immune system functioning, the interferon system, the profile of cytokines during the period of exacerbation of PID in women; to develop targeted immunotherapy using hexapeptide with assessment of its effectiveness. The studied immunocompromised women 20-40 years old with exacerbation of PID were divided into study groups (SG): SG1 (n=22), SG2 (n=70) before treatment; SG1a, SG1 receiving standard therapy; SG2a, SG2, receiving standard therapy and hexapeptide (HP, Imunofan®). The parameters of cellular and humoral immunity, levels of serum interferons, cytokines were determined. During exacerbation of PID, a decrease in IFNα was in both groups and IFNγ, more pronounced in SG1. In SG1, the levels of IL6, TNFα were increased, the level of IL8 was decreased. In SG2, the level of IL6 was increased. An increase in IL4, IL10 was noted in both groups. Against the background of IFNα, IFNγ deficiency and cytokine imbalance, a significant decrease in T-lymphocytes, T-helper cells, B-lymphocytes was observed in both study groups. After standard treatment, there was no recovery of IFNα, IFNγ. Only TNFα decreased, the levels of IL1β, IL6 were increased at the end of treatment, there was no increase in IL4, IL10 and restoration of cellular and humoral immunity. It leads to maintaining chronic inflammation and exacerbation of PID within 3 months after treatment. After immunotherapy including fHP, IFNα was restored in 50% cases. There was a decrease in IL1β, TNFα without significant changes in the levels of IL8, IL18. Resolution of inflammation was accompanied by an increase in IL10. The modulating effect of fHP on interferons and cytokines contributed to the restoration of T-cell and humoral immunity, which is related to the onset of clinical remission of PID at an earlier time and an increase in the duration of the inter-relapse period. The positive effectiveness of immunotherapy with Imunofan® is due to its pleiotropic effects, which provides significant advantages compared to the use of standard therapy only.

Keywords

chronic inflammatory diseases of the genital tract, immunocompromise, immunotherapy, hexapetide, cytokines, interferons.

About the authors

Irina Vadimovna Nesterova

Federal State Budgetary Institution of Higher Professional Education «Kuban State Medical University» of the Ministry of Healthcare of the Russian Federation, Krasnodar, Russian Federation;
Peoples' Friendship University of Russia named after Patrice Lumumba, Moscow, Russian Federation

Email: inesterova1@yandex.ru
ORCID iD: 0000-0001-6071-4409
SPIN-code: 4714-2488
Scopus Author ID: 56553330300
ResearcherId: A-8785-2016

Doctor of Medical Sciences (MD), Professor, Chief Researcher, Department of Clinical and Experimental Immunology and Molecular Biology, Central Scientific Research Laboratory,

Professor of the Department of Clinical Immunology, Allergology and Adaptology Faculty of Continuing Medical Education of the Medical Institute

Russian Federation, 1. 350063, Russia, Krasnodar, st. Mitrofana Sedina, 4 2. 117198, Russia, Moscow, st. Miklouho-Maklaya, 6

Svetlana Valentinovna Kovaleva

Federal State Budgetary Institution of Higher Professional Education «Kuban State Medical University» of the Ministry of Healthcare of the Russian Federation, Krasnodar, Russian Federation

Email: 3483335@mail.ru
ORCID iD: 0000-0002-9604-5806
SPIN-code: 8289-5342
Scopus Author ID: 55535685400
ResearcherId: AAB-3408-2020

Doctor of Medical Sciences (MD), Associate Professor, senior researcher of the department of clinical and experimental immunology and molecular biology of the Central Scientific Research Laboratory, Associate Professor of the Department of Clinical Immunology, Allergology and Laboratory Diagnostics of FAT and PRS