FREQUENCY OF POLYMORPHISM OF THE C-589T IL4 AND G-1082A IL10 GENES IN CHILDREN WITH NEW CORONAVIRUS INFECTION



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Abstract

Immune responses are involved in the initiation and development of COVID-19. Compared with mild COVID-19 cases, serum interleukins levels were significantly increased in severe and critical COVID-19 patients. Increases in IL-4 and IL-10 are associated with disease severity. The C-589T polymorphism of IL-4 gene is associated with increased promoter activity of gene. Allelic variants GA and GG -1082 of IL-10 gene have greater activity compared to the AA -1082  IL-10.

The purpose was to study the frequency of occurrence of polymorphic variants of the C-589T IL4 and G-1082A IL10 genes in children with a new coronavirus infection in the population of the  Crimea.

Methods. Examined: 68 patients aged 0 to 14 years with a diagnosis of moderate and severe NCI, 100 adult patients (45.6±6.14 years). The frequency of occurrence of polymorphisms of the C-589T IL4 and G-1082A IL10 genes was analyzed.

Results. The CC and CT variants of the C-589T  IL4  in the group of children  were more common than the TT C-589T IL4 variants. Statistically significant differences in the frequency of occurrence of the mutant  CC  genotype of the C-589T  IL4 were shown between groups of children and adults. Statistic analysis did not reveal any genotype differences with disease in either children or adults. Analysis of the prevalence of G-1082A IL10 genotypes showed that in children the most common is GA, the same trend is typical for adults and control group.

Conclusions. Analysis of the odds ratio showed that there was no pathogenetic significance between the polymorphism of the C-589T IL4 and G-1082A IL10 genes and the risk of developing a new coronavirus infection in the studied groups.

About the authors

Elizaveta Sergeevna Ageeva

V.I. Vernadsky Crimean Federal University
Order of Labor Red Banner Medical Institute named after S.I. Georgievsky

Email: ageevaeliz@rambler.ru
ORCID iD: 0000-0003-4590-3580

Doctor of Medical Sciences, Associated Professor, Head of the Department of Medical Biology

Russian Federation

Remzye Narimanovna Ablaeva

V.I. Vernadsky Crimean Federal University
Order of Labor Red Banner Medical Institute named after S.I. Georgievsky

Email: ablaeva.remzie@mail.ru

Assistant professor, Department of Medical Biology 

Natalya Victorovna Rymarenko

V.I. Vernadsky Crimean Federal University
Order of Labor Red Banner Medical Institute named after S.I. Georgievsky

Email: rymarenko.nv@mail.ru

Doctor of Medical Sciences, Professor, Professor of the Department of Pediatrics with a course in childhood infectious diseases 

Igor Anatolyevich Yatskov

V.I. Vernadsky Crimean Federal University
Order of Labor Red Banner Medical Institute named after S.I. Georgievsky

Email: egermd@yandex.ru

PhD, Associate Professor, Department of Internal Medicine No. 2

Vladimir Alexeevich Beloglazov

V.I. Vernadsky Crimean Federal University
Order of Labor Red Banner Medical Institute named after S.I. Georgievsky

Email: biloglazov@mail.ru

Doctor of Medical Sciences, Professor, Head of the Department of Internal Medicine No. 2 

Anna Alexandrovna Zhukova

V.I. Vernadsky Crimean Federal University
Order of Labor Red Banner Medical Institute named after S.I. Georgievsky

Author for correspondence.
Email: anna_crimea09@mail.ru

PhD, Associate Professor, Department of Medical Biology

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Copyright (c) Ageeva E.S., Ablaeva R.N., Rymarenko N.V., Yatskov I.A., Beloglazov V.A., Zhukova A.A.

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