POST-COVID-19 SYNDROME: TO THE DISCUSSION ABOUT THE TIMING OF THE OFFENSIVE



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Abstract

Summary. Introduction. Post-COVID syndrome (alternatively: chronic COVID syndrome, post-acute sequelae of COVID-19, long-haul COVID, long COVID, PASC, CCS) is a state of permanent or permanent presence of symptoms of a pathological process after COVID-19. Currently, there is no consensus on the timing of the onset of post-COVID-19 syndrome.The purpose of this study was to analyze the appearance of some post-COVID symptoms 1, 2 and 3 months after infection with the SARS-Cov-2 virus.Materials and methods. The analysis of clinical and laboratory data of 59 medical workers who had a mild or moderate form of COVID-19 was carried out. Three groups were formed: with the assessment of post-COVID-19 changes 1 month after the onset of the disease, with the detection of changes after 2 months, with the detection of violations after 3 months.Results and discussion. It was found that 57.7% of respondents complained of fatigue, weakness, sleep disorders in the first month of observation, after 2 months the frequency of complaints decreased by 42.3%, by 3 months it increased again by 15.6%. A month after COVID-19, several cases were recorded when employees were unable to perform any, even very light, work, however, by 3 months of follow-up, 96.2% of the surveyed declared full recovery of efficiency. The appearance of muscle, joint, and spinal pain was reported more often in the first month after COVID-19, then the number of complaints decreased by half to 23-25% of the total number of observations. The assessment of the severity of the infection among the respondents of the three groups did not reveal significant differences between the data in 1, 2 and 3 months after COVID-19.Conclusion. An analysis of some post-COVID symptoms showed that in mild and moderate COVID-19, manifestations are observed 1, 2 and 3 months after infection with the SARS-Cov-2 virus. A multidirectional dynamics of changes was revealed, more often accompanied by a decrease in the manifestation of post-COVID syndrome 2 months after coronavirus infection, which may create a false impression of the absence of signs of post-COVID syndrome during this period.

About the authors

Olga V. Berdiugina

Institute of Immunology and Physiology UrB RAS, Ekaterinburg, Russia

Author for correspondence.
Email: berolga73@rambler.ru
ORCID iD: 0000-0003-3479-9730
SPIN-code: 5230-7435
Scopus Author ID: 6504489044
ResearcherId: O-1102-2019

Ph.D., Dr.Sci. (Biol), Lead Researcher of the Inflammation Immunology Laboratory

Russian Federation, 106 ,Pervomayskaya street, Ekaterinburg, 620049

References

  1. Methodological recommendations of the Ministry of Health of the Russian Federation dated October 26, 2023 Prevention, diagnosis and treatment of new coronavirus infection (COVID-19). Version 18. (In Russ.) https://www.consultant.ru/document/cons_doc_LAW_347896
  2. Order of the Ministry of Health of the Russian Federation dated November 12, 2021 No. 1051n On approval of the Procedure for giving informed voluntary consent to medical intervention and refusal of medical intervention, forms of informed voluntary consent to medical intervention and forms of refusal of medical intervention (In Russ.) https://base.garant.ru/403111701
  3. Akbarialiabad H., Taghrir M.H., Abdollahi A., Ghahramani N., Kumar M., Paydar S., Razani B., Mwangi J., Asadi-Pooya A.A., Malekmakan L., Bastani B. Long COVID, a comprehensive systematic scoping review. Infection, 2021, Vol. 49, no. 6, pp. 1163-1186, PMID: 34319569, PMCID: PMC8317481 https://doi.org/10.1007/s15010-021-01666-x
  4. Castanares-Zapatero D., Chalon P., Kohn L., Dauvrin M., Detollenaere J., Maertens de Noordhout C., Primus-de Jong C., Cleemput I., Van den Heede K. Pathophysiology and mechanism of long COVID: a comprehensive review. Ann Med., 2022, Vol. 54, no. 1, pp. 1473-1487, PMID: 35594336, PMCID: PMC9132392 https://doi.org/10.1080/07853890.2022.2076901
  5. Chippa V., Aleem A., Anjum F. Post-Acute Coronavirus (COVID-19) Syndrome. In: StatPearls. Treasure Island: StatPearls Publishing; 2024, PMID: 34033370 https://www.ncbi.nlm.nih.gov/books/NBK570608
  6. Förster C., Colombo M.G., Wetzel A.J., Martus P., Joos S. Persisting Symptoms After COVID-19. Dtsch Arztebl Int., 2022, Vol. 119, no. 10, pp. 167-174, PMID: 35236547, PMCID: PMC9215272 https://doi.org/10.3238/arztebl.m2022.0147
  7. Koc H.C., Xiao J., Liu W., Li Y., Chen G. Long COVID and its Management. Int J Biol Sci., 2022, Vol. 18, no. 12, pp. 4768-4780, PMID: 35874958, PMCID: PMC9305273 https://doi.org/10.7150/ijbs.75056
  8. Mahase E. Long covid could be four different syndromes, review suggests. BMJ., 2020, Vol. 371, pp. m3981, PMID: 33055076 https://doi.org/10.1136/bmj.m3981
  9. Monje M., Iwasaki A. The neurobiology of long COVID. Neuron., 2022, Vol. 110, no. 21, pp. 3484-3496, PMID: 36288726, PMCID: PMC9537254 https://doi.org/10.1016/j.neuron.2022.10.006
  10. Proal A.D., VanElzakker M.B., Aleman S., Bach K., Boribong B.P., Buggert M., Cherry S., Chertow D.S., Davies H.E., Dupont C.L., Deeks S.G., Eimer W., Ely E.W., Fasano A., Freire M., Geng L.N., Griffin D.E., Henrich T.J., Iwasaki A., Izquierdo-Garcia D., Locci M., Mehandru S., Painter M.M., Peluso M.J., Pretorius E., Price D.A., Putrino D., Scheuermann R.H., Tan G.S., Tanzi R.E., VanBrocklin H.F., Yonker L.M., Wherry E.J. SARS-CoV-2 reservoir in post-acute sequelae of COVID-19 (PASC). Nat Immunol., 2023, Vol. 24, no. 10, pp. 1616-1627, PMID: 37667052 https://doi.org/10.1038/s41590-023-01601-2
  11. Raveendran A.V. Long COVID-19: Challenges in the diagnosis and proposed diagnostic criteria. Diabetes Metab Syndr., 2021, Vol. 15, no. 1, pp. 145-146, PMID: 33341598, PMCID: PMC7737559 https://doi.org/10.1016/j.dsx.2020.12.025

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