Email this article ASSOCIATION OF POLYMORPHIC MARKERS IN INNATE IMMUNITY RECEPTOR GENES WITH THE RISK OF PRIMARY ADRENAL INSUFFICIENCY
- Authors: Rasskazova N.D.1, Meremianina E.A.2, Kalyuzhnaya N.O.1, Abramova N.D.1, Budanova E.V.3, Diakov I.N.1
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Affiliations:
- I. Mechnikov Research Institute of Vaccines and Sera
- I. Mechnikov Research Institute of Vaccines and Sera,FSBEI FPE "Russian Medical Academy of Continuous Professional Education" MOH Russia.
- Erisman Institute of Public Health (and Healthcare Management), Sechenov University
- Section: Joint Immunology Forum 2024
- URL: https://rusimmun.ru/jour/article/view/16798
- DOI: https://doi.org/10.46235/1028-7221-16798-AOP
- ID: 16798
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Abstract
Primary adrenal insufficiency is a disease resulting from bilateral destruction of the adrenal cortex. The most common etiological factors are autoimmune disorders and infectious diseases, which indicates the key role of the immune system in the development of this pathology. Activation of innate immune receptors leads to transcription of genes for pro-inflammatory cytokines and type I interferons, which contributes to the further development of the inflammatory process, activating both adaptive and innate immunity. The role of pattern recognition receptors and type I interferons has been previously shown in many autoimmune pathologies, but their significance in primary adrenal insufficiency is still not well understood. To gain a broader understanding of the occurring processes, innate immune receptors are being studied at both the molecular and genetic levels. Thus, the purpose of our work was to study polymorphic markers in the genes of interferon, NOD- and RIG-like receptors and their association with the risk of developing primary adrenal insufficiency. The biomaterial was collected from patients with primary adrenal insufficiency and from healthy individuals and was examined using real-time polymerase chain reaction. It was found that among the six polymorphic markers (rs2257167 in the IFNAR1 gene, rs2229207 in the IFNAR2 gene, rs2075822 in the NOD1 gene, rs8057341 and rs3135499 in the NOD2 gene and rs1990760 in the IFIH1 gene), there are only two sufficient predictors of the risk of developing primary adrenal gland disease: rs2257167 (IFNAR1) and rs2229207 (IFNAR2). The association of heterozygous genotypes of the polymorphic markers rs2257167 (IFNAR1) and rs2229207 (IFNAR2) with the risk of developing pathology, as well as the protective role of the CC genotype of the polymorphic marker rs2257167 (IFNAR1) was shown. The results obtained can be used for early diagnostics of the disease. These data can contribute to a better understanding of the pathogenesis of primary adrenal insufficiency and serve as the basis for further research in the field of personalized medicine. These markers can also be studied in connection with the severity of primary adrenal insufficiency, complications, as well as in connection with the effectiveness of the therapy.
About the authors
Nadezhda D. Rasskazova
I. Mechnikov Research Institute of Vaccines and Sera
Author for correspondence.
Email: neonovita@mail.ru
ORCID iD: 0000-0003-0729-5940
SPIN-code: 8940-6505
Junior Researcher fellow of Laboratory of Molecular Immunology
Russian Federation, 105064 Moscow, Maly Kazenny per., 5AEkaterina A. Meremianina
I. Mechnikov Research Institute of Vaccines and Sera,FSBEI FPE "Russian Medical Academy of Continuous Professional Education" MOH Russia.
Email: ekaterina@meremianina.ru
ORCID iD: 0000-0003-4334-1473
SPIN-code: 9721-4839
candidate of medical science, research fellow of Laboratory of Molecular Immunology, I. Mechnikov Research Institute of Vaccines and Sera, Senior Lecturer at the Department of Virology FSBEI FPE "Russian Medical Academy of Continuous Professional Education" MOH Russia.
Russian FederationNatalia O. Kalyuzhnaya
I. Mechnikov Research Institute of Vaccines and Sera
Email: nat_kalyuzhnaya@mail.ru
ORCID iD: 0000-0002-1668-1846
SPIN-code: 7169-6807
Junior Researcher fellow of Laboratory of Molecular Immunology
Russian FederationNatalya D. Abramova
I. Mechnikov Research Institute of Vaccines and Sera
Email: and960911@gmail.com
ORCID iD: 0000-0002-7307-0515
SPIN-code: 1763-8942
Junior Researcher fellow of Laboratory of Molecular Immunology
Russian FederationElena V. Budanova
Erisman Institute of Public Health (and Healthcare Management), Sechenov University
Email: e.v.budanova@mail.ru
ORCID iD: 0000-0003-1864-5635
Candidate of medical science, assistant professor of The Department of microbiology, virology and immunology, Erisman Institute of Public Health (and Healthcare Management), Sechenov University
Russian FederationIlya N. Diakov
I. Mechnikov Research Institute of Vaccines and Sera
Email: dyakov.ilya@gmail.com
ORCID iD: 0000-0001-5384-9866
SPIN-code: 1854-0958
Candidate of Biological Sciences, Head of the Laboratory of Immunoglobulin Biosynthesis
Russian FederationReferences
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СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).