RATIO OF IMMUNE INDICES IN WOMEN OF THE SEMI-ARID REGION



Cite item

Full Text

Abstract

Environmental and climatic factors have a significant impact on the immune system, shaping its composition and functions. The semiarid region of Aleppo, characterized by hot, dry summers and moderate, wet and cold winters, is also characterized by environmental pollution such as air pollutants and industrial chemicals. The interaction of these environmental and climatic factors can impair immune function by causing inflammatory responses, compromising the integrity of immune cells, and impairing the body's ability to mount an effective immune response. To date, the physiological characteristics of the parameters of the human blood system and the development of physiological reactions of adaptive immune homeostasis depending on the territory of residence have not been sufficiently studied. In this work, we studied the state of immune indices in women living in the semi-arid region. 30 women aged from 20 to 60 years without chronic and acute diseases were examined. Immunocompetence was assessed using white blood cell count, lymphocyte subset analysis and calculation of immune indices including neutrophil to lymphocyte ratio (NLR), lymphocyte to monocyte ratio (LMR), systemic inflammatory response index (SIRI), immunoregulatory index (CD4+/CD8+) and lymphoproliferation ratio and apoptosis (CD10+ / CD95+ and CD71+ / CD95+). The results of the analysis showed that the median NLR was 2.18 (1.50-2.90), LMR 6.66 (5.47-8.87), SIRI 0.64 (0.45-0.98), immunoregulatory index 0.99 (0.84-1.27) and the ratio of lymphoproliferation processes to apoptosis (CD10+/CD95+ and CD71+/CD95+) 0.95 (0.65-1.29) and 0.94 (0.78-1 ,11), respectively, which indicates a stressful state of immune homeostasis and signs of premature aging of the immune system. Neutrophil-lymphocyte ratio (NLR), lymphocyte-monocyte ratio (LMR), systemic inflammatory response index (SIRI), immunoregulatory index (CD4+/CD8+) and lymphoproliferation-apoptosis ratio were determined. (CD10+/CD95+ and CD71+/CD95+) in the examined women of the semiarid climate zone of residence, emphasizes the stressful level of immune homeostasis. The results obtained highlight the need for systematic individual biomedical monitoring to maintain immune homeostasis in populations inhabiting similar environmental conditions.

About the authors

Mohammad Sohib Kabbani

N. Laverov Federal Center for Integrated Arctic Research of the Ural Branch of the Russian Academy of Sciences (FECIAR UrB RAS), Arkhangelsk

Email: sohibmsk@hotmail.com
ORCID iD: 0000-0002-2330-7123
SPIN-code: 7840-2899
Scopus Author ID: 57209616875
ResearcherId: AAC-9877-2022

 researcher 

Russian Federation, 163000, Russia, Arkhangelsk, avenue Lomonosova 249, 11.

Lyubov Stanislavovna Shchegoleva

N. Laverov Federal Center for Integrated Arctic Research of the Ural Branch of the Russian Academy of Sciences (FECIAR UrB RAS)

Email: shchegoleva60@mail.ru
ORCID iD: 0000-0003-4900-4021
SPIN-code: 6859-2123
Scopus Author ID: 6603940197

Doctor of Biological Sciences, Professor, Chief Researcher, head of laboratory of N. Laverov Federal Center for Integrated Arctic Research of the Ural Branch of the Russian Academy of Sciences (FECIAR UrB RAS)

Russian Federation, 163000, Russia, Arkhangelsk, avenue Lomonosova 249

Elizaveta Yurievna Shashkova

N. Laverov Federal Center for Integrated Arctic Research of the Ural Branch of the Russian Academy of Sciences (FECIAR UrB RAS)

Author for correspondence.
Email: eli1255@yandex.ru
ORCID iD: 0000-0002-1735-6690
SPIN-code: 8137-0571

к.б.н., старший научный сотрудник

Russian Federation, 163000, Russia, Arkhangelsk, avenue Lomonosova 249

References

  1. Biard C., Monceau K., Motreuil S., Moreau J. Interpreting immunological indices: The importance of taking parasite community into account. An example in blackbirds Turdus merula. Methods in Ecology and Evolution, 2015, Vol. 6, no. 8, pp. 960-972. _ https://besjournals.onlinelibrary.wiley.com/doi/full/10.1111/2041-210X.12371 [doi: 10.1111/2041-210X.12371]
  2. Dang H., Mao W., Wang S., Sha J., Lu M., Cong L., Meng X., Li H. Systemic inflammation response index as a prognostic predictor in patients with acute ischemic stroke: A propensity score matching analysis. Front Neurol, 2023, vol. 13, 1049241. _ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9871574/ [doi: 10.3389/fneur.2022.1049241]
  3. Demas G.E., Zysling D.A., Beechler B.R., Muehlenbein M.P., French S.S. Beyond phytohaemagglutinin: assessing vertebrate immune function across ecological contexts. Journal of Animal Ecology, 2011, Vol. 80, no. 4, pp. 710-730. _ https://pubmed.ncbi.nlm.nih.gov/21401591/ [doi: 10.1111/j.1365-2656.2011.01813.x]
  4. Elfeky S.E.F., Ali A., Moazen E.M., Alhassoon M.H., Elzanaty N.A., Alazmi N.M., Wu L., Saleh M.M. Systemic inflammatory response index as an independent predictor of severity in patients with obstructive sleep apnea. The Egyptian Journal of Bronchology, 2024, Vol. 18, no. 1, 1. _ https://ejb.springeropen.com/articles/10.1186/s43168-023-00253-y [doi: 10.1186/s43168-023-00253-y]
  5. Ferrucci P.F., Gandini S., Battaglia A., Alfieri S., Di Giacomo A.M., Giannarelli D., Cappellini G.C.A., de Galitiis F., Marchetti P., Amato G., Lazzeri A., Pala L., Cocorocchio E., Martinoli C. Baseline neutrophil-to-lymphocyte ratio is associated with outcome of ipilimumab treated metastatic melanoma patients. Br J Cancer, 2015, Vol. 112, pp. 1904–1910. _ https://pubmed.ncbi.nlm.nih.gov/26010413/ [doi: 10.1038/bjc.2015.180]
  6. Hegemann A., Pardal S., Matson, K.D. Indices of immune function used by ecologists are mostly unaffected by repeated freeze-thaw cycles and methodological deviations. Frontiers in Zoology, 2017, Vol. 14, no. 1, 43. _ https://pubmed.ncbi.nlm.nih.gov/28883887/ [doi: 10.1186/s12983-017-0226-9]
  7. Isidori A.M., Hasenmajer V., Sciarra F., Venneri M.A.. Environmental Impact on Immune System. In: Environmental Endocrinology and Endocrine Disruptors. 1st ed. Eds. Pivonello R., Diamanti-Kandarakis E., Springer Cham, 2023, pp. 363-395. _ https://link.springer.com/referenceworkentry/10.1007/978-3-030-38366-4_13-1 [doi: 10.1007/978-3-030-39044-0_13]
  8. Kondo Y., Abe S., Toko H., Hirota T., Takahashi H., Shimizu M., Noma H., Tsuboi H., Matsumoto I., Inaba T., Sumida T. Effect of climatic environment on immunological features of rheumatoid arthritis. Scientific Reports. 2023, Vol. 13, no. 1, 1304. _ https://www.nature.com/articles/s41598-022-27153-3 [doi: 10.1038/s41598-022-27153-3]
  9. Loftus L.V., Amend S.R., Pienta K.J. Interplay between Cell Death and Cell Proliferation Reveals New Strategies for Cancer Therapy. Int J Mol Sci, 2022, Vol. 23, no, 9, 4723. _ https://pubmed.ncbi.nlm.nih.gov/35563113/ [doi: 10.3390/ijms23094723]
  10. Luz Correa B., Ornaghi A.P., Cerutti Muller G., Engroff P., Pestana Lopes R., Gomes da Silva Filho I., Bosch J.A., Bonorino C., Bauer M.E. The inverted CD4:CD8 ratio is associated with cytomegalovirus, poor cognitive and functional states in older adults. Neuroimmunomodulation, 2014, Vol. 21, no. 4, pp. 206-212. _ https://pubmed.ncbi.nlm.nih.gov/24504177/ [doi: 10.1159/000356827]
  11. Martens A, Wistuba-Hamprecht K, Yuan J, Postow MA, Wong P, Capone M, Madonna G., Khammari A., Schilling B., Sucker A., Schadendorf D., Martus P., Dreno B., Ascierto P.A., Wolchok J.D., Pawelec G., Garbe C., Weide B. Increases in absolute lymphocytes and circulating CD4 and CD8 T cells are associated with positive clinical outcome of melanoma patients treated with Ipilimumab. Clin Cancer Res, 2016, Vol. 22, pp. 4848–4858. _ https://pubmed.ncbi.nlm.nih.gov/27169993/ [doi: 10.1158/1078-0432.CCR-16-0249]
  12. Ren H., Liu X., Wang L., Gao Y. Lymphocyte-to-Monocyte Ratio: A Novel Predictor of the Prognosis of Acute Ischemic Stroke. J Stroke Cerebrovasc Dis, 2017, Vol. 26, no. 11, pp. 2595-2602. _ https://pubmed.ncbi.nlm.nih.gov/28847530/ [doi: 10.1016/j.jstrokecerebrovasdis.2017.06.019]
  13. Selvaraj R. K., Shanmugasundaram R., Rengasamy R. The use and abuse of immune indices in nutritional immunology studies. Journal of Applied Poultry Research, 2016, Vol. 25, no. 2, pp. 284–291. _ https://www.sciencedirect.com/science/article/pii/S105661711930234X [doi: 10.3382/japr/pfv077]
  14. Vinkler M., Albrecht T. Handling ‘immunocompetence’ in ecological studies: do we operate with confused terms?. Journal of Avian Biology, 2011, Vol. 42, no. 6, pp. 490-493. _ https://www.cabidigitallibrary.org/doi/full/10.5555/20123039335 [doi: 10.1111/j.1600-048X.2011.05499.x]
  15. Zahorec R. Neutrophil-to-lymphocyte ratio, past, present and future perspectives. Bratisl Lek Listy, 2021, Vol. 122, no. 7, pp. 474-488. _ https://pubmed.ncbi.nlm.nih.gov/34161115/ [doi: 10.4149/BLL_2021_078]

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c) Kabbani M.S., Shchegoleva L.S., Shashkova E.Y.

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: серия ПИ № 77 - 11525 от 04.01.2002.


This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies