DENTAL ANOMALIES IN CONGENITAL ERROR OF IMMUNITY
- Authors: Sarkisyan N.G.1, Tuzankina I.A.2, Kataeva N.N.3, Melikyan A.H.4, Оsipova I.M.4
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Affiliations:
- Federal State-Financed Educational Institution of Higher Education Ural state medical university of the Ministry of Health of the Russian Federation, Yekaterinburg (FSFET HE USMU) Institute of Immunology and Physiology Ural Branch of the Russian Academy of Sciences, Yekaterinburg (FGBUN IIP UB RAS)
- Institute of Immunology and Physiology Ural Branch of the Russian Academy of Sciences, Yekaterinburg (FGBUN IIP UB RAS)
- Federal State-Financed Educational Institution of Higher Education Ural state medical university of the Ministry of Health of the Russian Federation
- Federal State-Financed Educational Institution of Higher Education Ural state medical university of the Ministry of Health of the Russian Federation, Yekaterinburg (FSFET HE USMU)
- Section: Joint Immunology Forum 2024
- URL: https://rusimmun.ru/jour/article/view/16812
- DOI: https://doi.org/10.46235/1028-7221-16812-DAI
- ID: 16812
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Abstract
Developmental disorders of the teeth and maxillofacial region are part of a symptoms complex that often occur with inborn errors of the immune system. The purpose of the study is to identify the frequency of various dentofacial anomalies occurrence in patients with diagnosed immunodeficiencies.
Materials and methods. The study involved 64 patients of the Sverdlovsk Regional Clinical Hospital №1 and the Regional Children's Clinical Hospital (Ekaterinburg) with various diagnoses: combined immunodeficiencies, antibody defects, autoinflammatory disorders, defects in the number and functions of phagocytes, defects in immune dysregulation, complement defects, unverified diagnosis with signs of immunodeficiency. All patients underwent examination of the oral cavity, hard dental tissues, periodontal tissue and jaw bone tissue.
Results and discussions. It was found that an anomaly in jaw size is characteristic of all patients studied groups, except for the group with complement defects. Along with this, such pathology as quantitative and qualitative changes in teeth was identified in four classification groups: “combined immunodeficiencies” (25% of cases from the subgroup), “antibody defects” (31% of cases from the subgroup), “phagocyte defects” (10 % of cases from the subgroup), “immune dysregulation defects” (50% of cases from the subgroup). The same frequency of occurrence of tissue repair defects: in “combined immunodeficiencies” (16.6% of cases from the subgroup), “autoinflammatory disorders” (26.7% of cases from the subgroup), “phagocyte defects” (10% of cases from the subgroup), in “unverified diagnoses” (20% of cases from the subgroup).
The highest percentage of quantitative manifestations of such anomalies as jaw size (26% of cases from the entire study group) and facial dysmorphism (27% of cases from the entire study group).
In patients with “combined immunodeficiencies” all the dental anomalies described in the work were identified. However, the highest percentage of people in this group had delayed teething (33.3%) and facial dysmorphism (33%). The only patient diagnosed with “complement defects” had no dental anomalies. The minimum number of manifestations of the studied anomalies was observed in groups with “antibody defects” and “immune dysregulation defects”.
Conclusion. The accumulated experience in describing various dental diagnoses will contribute to the creation of dental criteria for the diagnosis of primary immunodeficiencies.
About the authors
Narine Grishaevna Sarkisyan
Federal State-Financed Educational Institution of Higher Education Ural state medical university of the Ministry of Health of the Russian Federation, Yekaterinburg (FSFET HE USMU)Institute of Immunology and Physiology Ural Branch of the Russian Academy of Sciences, Yekaterinburg (FGBUN IIP UB RAS)
Email: narine_25@mail.ru
Doctor of Medical Sciences, professor of postgraduate department , Associate Professor of the Department of Therapeutic Dentistry and Propedeutics of Dental Diseases , Ural State Medical University, Yekaterinburg
Irina Alexandrivna Tuzankina
Institute of Immunology and Physiology Ural Branch of the Russian Academy of Sciences, Yekaterinburg (FGBUN IIP UB RAS)
Email: ituzan@yandex.ru
honored worker of science, doctor of medicine, professor
Natalia Nikolaevna Kataeva
Federal State-Financed Educational Institution of Higher Education Ural state medical university of the Ministry of Health of the Russian Federation
Email: kataeva.nn@mail.ru
ORCID iD: 0000-0002-2847-8810
PhD, associate professor, assistant professor of General Chemistry department
Russian FederationArsen Henrikovich Melikyan
Federal State-Financed Educational Institution of Higher Education Ural state medical university of the Ministry of Health of the Russian Federation, Yekaterinburg (FSFET HE USMU)
Email: arsen.melikyan.01@mail.ru
5th year student of the Dental Faculty
Izabella Mgerovna Оsipova
Federal State-Financed Educational Institution of Higher Education Ural state medical university of the Ministry of Health of the Russian Federation, Yekaterinburg (FSFET HE USMU)
Author for correspondence.
Email: oim2001@bk.ru