Email this article NAKED MOLE-RAT MACROPHAGE POLARIZATION
- Authors: Gorshkova E.A.1,2, Purtova S.K.1, Dvorianinova E.M.1, Vyssokikh M.Y.2,3, Nedospasov S.A.1,2,4
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Affiliations:
- Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia
- Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, Russia
- FSBI «National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I.Kulakov», Ministry of Health of the Russian Federation
- Division of Immunobiology and Biomedicine, Center of Genetics and Life Sciences, Sirius University of Science and Technology, Federal Territory Sirius, Russia
- Section: Joint Immunology Forum 2024
- URL: https://rusimmun.ru/jour/article/view/16913
- DOI: https://doi.org/10.46235/1028-7221-16913-NMR
- ID: 16913
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Abstract
Abstract
The naked mole-rat (NMR) is a unique long-lived rodent with low cancer incidence. Understanding the molecular mechanisms that NMR evolved to control aging and tumorigenesis is important for biomedicine.
It is commonly accepted that the immune system has essential functions in the tumor growth control in animals. In-depth study of the NMR immune system has recently begun, thus peculiarities of antitumor response in these animals remain undiscovered. However, it was shown that myelopoiesis predominates in NMR, therefore it can be assumed that the innate immune cells in the naked mole rat contribute to the successful control of the cancer incidence and tumor growth.
This brief provides an overview of ongoing research into the properties of naked mole rat macrophages. Recent study shown that naked mole rat peritoneal macrophages are capable of acquiring an inflammatory phenotype (M1) but polarization into an anti-inflammatory phenotype (M2) under standard stimulus is limited. A more in-depth study using transcriptome sequencing and immunometabolic profiling in novel in vitro model of naked mole rat bone marrow macrophages suggested by our group revealed non-canonical features of M1 as well as M2 phenotypes of naked mole rat macrophages, which can be associated with the evolutionary adaptation of the species. Continued study of the different polarization conditions of naked mole rat macrophages is important to determine unique adaptations in NMR antitumor immunity.
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About the authors
Ekaterina A. Gorshkova
Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia;Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, Russia
Email: gorshsama@gmail.com
PhD, Research Associate, laboratory of molecular mechanisms of immunity
Russian Federation, 119991, г. Москва, ул. Вавилова, д. 32. ИМБ РАН; 119992, Москва, Ленинские горы, дом 1, стр 40Svetlana K. Purtova
Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia
Email: skpurtova@mail.ru
aboratory assistant
Russian Federation, 32 Vavilov St, Moscow 119991 Russian FederationEkaterina M. Dvorianinova
Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia
Email: dvorianinova.em@phystech.edu
Junior Research Associate
Russian Federation, 32 Vavilov St, Moscow 119991 Russian FederationMikhail Yu. Vyssokikh
Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, Russia;FSBI «National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I.Kulakov», Ministry of Health of the Russian Federation
Email: mikhail.vyssokikh@gmail.com
PhD,
Russian Federation, 119992, Moscow, Leninskie Gory, 1, p. 40,; 117198, Mpscow, Akademika Oparina st, 4Sergei A. Nedospasov
Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia;Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, Russia;
Division of Immunobiology and Biomedicine, Center of Genetics and Life Sciences, Sirius University of Science and Technology, Federal Territory Sirius, Russia
Author for correspondence.
Email: sergei.nedospasov@gmail.com
PhD, MD (Biology), Professor, Full Member, Russian Academy of Sciences, Head, Laboratory of Molecular Mechanisms of Immunity, Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow; Head, Department of Molecular Immunology, Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University; Head, Division of Immunobiology and Biomedicine, Sirius University of Science and Technology
Russian Federation, Moscow; Moscow; Krasnodar RegionReferences
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