IN VITRO IMMUNOMODULATORY EFFECT OF OPISTHORCHIS FELINEUS HEMOZOIN ON DENDRITIC CELLS OF CHILDREN WITH BRONCHIAL ASTHMA



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Abstract

Abstract

In the case of a detailed consideration of the mechanisms of inflammation in atopic diseases, the predominance of the Th2 pathway of the adaptive immune response is noted. The Th2 immune response is characterized by increased levels of IL-4, IL-5, IL-13, triggering humoral and cell-mediated immune responses with the production of IgE, basophils, eosinophils and mast cells. Modern scientific research focuses on the immunoregulatory potential of helminths and their excretory products, which have potential for the pharmaceutical industry. It is known that the parasite in the host body is able to evade the immune response and can inhibit, alter and modify the current immune responses of the host body by producing immunomodulatory substances. Molecules of the excretory-secretory product, resulting from the co-evolution of the host and parasite, can suppress the type 2 immune response, while activating type 1 and type 17 responses. The immunosuppressive microenvironment created by helminths may not only help them evade the host's immune response, but also prevent serious damage to the body caused by excessive inflammation. The role of liver fluke in reducing inflammation in allergic diseases has been proven. The excretory-secretory molecule of the liver fluke (hemozoin) is a promising product of parasitic origin, having pronounced immunomodulatory properties, it is a dark brown insoluble biocrystal that is synthesized during the life of hematophagous parasites Rhodnius prolixus, Schistosoma mansoni, Plasmodium falciparum, Echinostoma trivolvis, Haemoproteus colum bae, Clonorchis sinensis and Plasmodium falciparum, Opisthorhis felineus. In this regard, the search for helminth-associated molecules that have an immunomodulatory effect, while also having low toxicity and immunogenicity, seems to be an urgent task.

The aim of the present study is to establish the effect of O. felineus hemozoin on the cytokine profile of DCs in patients with bronchial asthma.

It was shown that stimulation of DCs of the examined patients with the D. pteronyssinus antigen in combination with O. felineus hemozoin is associated with a high level of Th1-profile cytokines (IL1b, INFy), as well as high activity of Treg cells (IL-10).

Thus, liver fluke hemozoin is able to change the cytokine profile of DCs in patients with bronchial asthma. This property of native hemozoin isolated from O. felineus can be used to correct conditions associated with Th2 polarization of the immune response, which is a common feature of atopic diseases.

About the authors

Anasyasia Melenteva

“Siberian State Medical University” of the Ministry of Health of the Russian Federation

Email: anastasiaymelenteva@gmail.com
ORCID iD: 0009-0009-5600-5760
SPIN-code: 3079-5819
ResearcherId: KCY-0258-2024

postgraduate student of the Department of Faculty Pediatrics with a course of childhood diseases of the Faculty of Medicine

Russian Federation

Maria Podporina

“Siberian State Medical University” of the Ministry of Health of the Russian Federation

Email: podporina.ma@ssmu.ru
ORCID iD: 0000-0002-6398-2481
SPIN-code: 5973-7396
Scopus Author ID: 57193933503

PhD, Assistant of the Department of Faculty Pediatrics with a course of childhood diseases of the Faculty of Medicine

Russian Federation

Ludmila Ogorodova

“Siberian State Medical University” of the Ministry of Health of the Russian Federation

Email: edu@tomsk.gov.ru
ORCID iD: 0000-0002-2962-1076
SPIN-code: 4362-8431
Scopus Author ID: 7004641487
ResearcherId: S-5058-2016

Doctor of Medical Sciences, Professor, Corresponding Member. RAS, Honored Scientist of the Russian Federation, Professor of the Department of Faculty Pediatrics with a course of childhood diseases of the Faculty of Medicine

Russian Federation

Olga Fedorova

“Siberian State Medical University” of the Ministry of Health of the Russian Federation

Author for correspondence.
Email: olga.sergeevna.fedorova@gmail.com
ORCID iD: 0000-0002-7130-9609
SPIN-code: 5285-4593
Scopus Author ID: 57197113883
ResearcherId: AAC-8290-2022

Doctor of Medical Sciences, Professor, Vice-Rector for Scientific Work and Postgraduate Training, Head of the Department of Faculty Pediatrics with a course of childhood diseases of the Faculty of Medicine

Russian Federation

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