INDICATORS OF TRANSFORMING GROWTH FACTORS IN FEMALE PATIENTS WITH HUMAN PAPILLOMAVIRUS AND FERTILITY PROBLEMS



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Abstract

Abstract

The human papillomavirus (HPV) causes one of the most common sexually transmitted viral infections. HPV is the cause of changes in the multilayer, flat and metaplastic epithelium, which further leads to cervical intraepithelial neoplasia, with possible carcinogenesis of the cervix. The state of local and general immunity is a crucial factor in the implementation of viral infections, including PVI. The immune response aimed at preventing manifest and inapparative HPV infection. Cellular immunity provides a blocking effect on the persistence of the virus and, in some cases, promotes spontaneous regression of lesions. The involvement of cellular immunity in this pathological process proved by the detection of a large number of CD4+ and CD8+ lymphocytes in the infiltrate of regressing condillomatous lesions. In general, with HPV infection, there is a decrease in cellular immunity. One of the main roles in the regulation of the immune response in papillomavirus infection (PVI) assigned to soluble factors of intermolecular interaction, including transforming growth factors.

The aim of the study was to assess the levels of TFR β1, TFR β2, TFR α in women with papillomavirus infection (PVI) and reproductive disorders. The material was the blood serum of 75 female patients, aged 25 to 44 years. The patients were divided into 3 main groups: I- STIs with PVI, II- STIs without PVI, and III- control group. The 1st and 2nd main groups were divided into subgroups depending on reproductive disorders: 1 subgroup – without fertility disorders and 2 subgroup – with infertility. Biological material was collected after the women were examined and diagnosed. The prevailing hyperproduction of transforming growth factors β 1 and 2 in women with papillomavirus infection indicates immunosuppression in this category of patients. This can lead to impaired reproductive function due to physiological immunosuppression, upon the onset of pregnancy, and due to the persistence of the viral process, inducing disturbances in both local and systemic immune responses, which jeopardizes the normal functioning of the endometrial tissue and the tight attachment of the fetal egg to the villi of the endometrium and prolongation of pregnancy.

About the authors

T. A. Nevezhkina

"Pacific State Medical University", Vladivostok, Russia

Email: www.tanya.ru9292@mail.ru

Assistant Professor, Department of Normal and Pathological Physiology

Russian Federation, 2, Ostryakov Avenue, Vladivostok

E. V. Markelova

"Pacific State Medical University", Vladivostok, Russia

Email: tanya.ru9292@mail.ru

PhD, MD (Medicine), Professor, Head, Department of Normal and Pathological Physiology

Russian Federation, 2 Ostryakov Ave Vladivostok 690002

L. S. Matyshkina

"Pacific State Medical University", Vladivostok, Russia

Email: tanya.ru9292@mail.ru

PhD (Medicine), Associate Professor, Head, Department of Obstetrics and Gynecology

Russian Federation, 2 Ostryakov Ave Vladivostok 690002

S. V. Knysh

"Pacific State Medical University", Vladivostok, Russia

Email: s.knysh@m.tgmu.ru

PhD (Medicine), Associate Professor, Department of Normal and Pathological Physiology, Pacific State Medical University

Russian Federation, Vladivostok

K. A. Polyakova

"Pacific State Medical University", Vladivostok, Russia

Author for correspondence.
Email: enderprog@mail.ru

student of the Faculty of Medicine 

Russian Federation

I. N. Smolyakov

"Pacific State Medical University", Vladivostok, Russia

Email: enderprog@mail.ru

student of the Faculty of Medicine 

Russian Federation

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Copyright (c) Smolyakov I.N., Nevezhkina T.A., Knysh S.V., Matyshkina L.S., Markelova E.V., Polyakova K.A.

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