INFLUENCE HLA-DRA GENE RS8084 POLYMORPHISM AND THE DEVELOPMENT OF HIV1 INFECTION ON THE EXPRESSION OF INTERFERON-STIMULATING GENES MX2, IFNM1, ADAR1
- Authors: Jiemuratova G.1, Kadirov J.F.2, Rizaev J.A.1, Ziyadullaev S.K.2, Oslanov A.A.1, Fayzullaeva D.B.3, Kamalov Z.S.3, Dushanova G..1
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Affiliations:
- Samarkand State Medical University, Samarkand, Uzbekistan
- Institute of Immunology and Human Genomics, Academy of Sciences of the Republic of Uzbekistan
- Republican Center for AIDS Control of Uzbekistan
- Section: ORIGINAL ARTICLES
- Submitted: 17.02.2025
- Accepted: 26.07.2025
- URL: https://rusimmun.ru/jour/article/view/17095
- DOI: https://doi.org/10.46235/1028-7221-17095-IHD
- ID: 17095
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Abstract
AbstractIn individuals infected with HIV, the influence of rs8084 polymorphism suggests that certain alleles may slow disease progression at an older age, allowing people with specific genotypes to maintain higher CD4 levels even if they are infected later in life. This may indicate a more effective activation of the immune response with age. This study analyzes the distribution of HIV-1 patients by disease stages depending on age groups, as well as changes in CD4% levels and the expression of the MX2, IFNM1, and ADAR1 genes in infected patients. A total of 143 patients diagnosed with HIV-1, aged 14 to 66 years, were examined. The control group consisted of 67 practically healthy individuals aged 15 to 57 years, who were unrelated, had no clinical signs of HIV infection, and had no hereditary predisposition to the disease. The results show that the highest number of infections occurs in the third stage of the disease (symptomatic phase) among young individuals aged 14–35 years. At later stages of the disease, CD4% levels significantly decrease, indicating the progression of immune deficiency. A correlation was also identified between the HLA-DRA genotype and CD4% levels, highlighting the potential for a personalized approach to HIV treatment. Additionally, the study revealed a significant increase in the expression of the MX2, IFNM1, and ADAR1 genes in HIV-infected patients, confirming the activation of antiviral mechanisms in response to infection. The study demonstrated that HIV-1 infection is associated with significant changes in the immune system, as evidenced by a decrease in CD4% levels and an increase in the expression of key antiviral genes such as MX2, IFNM1, and ADAR1. Given the role of genetic factors, such as HLA-DRA polymorphism, in disease progression, the importance of a personalized treatment approach is emphasized.
Keywords
About the authors
Gulparshin Jiemuratova
Samarkand State Medical University, Samarkand, Uzbekistan
Email: gulparshin_76@mail.ru
ORCID iD: 0000-0002-7190-8548
Candidate of Medical Sciences, Senior Researcher at the Institute of Human Immunology and Genomics of the Academy of Sciences of the Republic of Uzbekistan
Uzbekistan, Address: 74 Ya. Gulyamova str., Tashkent, 100060Jonibek Faizullaevich Kadirov
Institute of Immunology and Human Genomics, Academy of Sciences of the Republic of Uzbekistan
Email: K.jon@mail.com
PhD, Docent, Head of the Course of Infectious Diseases of the FPGE
Uzbekistan, Address: 140100. Republic of Uzbekistan, Samarkand city, st. Amira Temura, house 18. Phone: +998 66 233 08 41,Jasur Alimdjanovich Rizaev
Samarkand State Medical University, Samarkand, Uzbekistan
Email: rizaev.j@mail.ru
Doctor of Medical Sciences, Professor of the Department of Public Health and Health Management
Uzbekistan, Address: 140100. Republic of Uzbekistan, Samarkand city, st. Amira Temura, house 18.Shukhrat Khudaiberdievich Ziyadullaev
Institute of Immunology and Human Genomics, Academy of Sciences of the Republic of Uzbekistan
Email: z.shukhrat@mail.ru
Doctor of Medical Sciences, Professor, Deputy Director for Research
Uzbekistan, Address: 74 Ya. Gulyamova str., Tashkent, 100060Absamat Abdurakhimovich Oslanov
Samarkand State Medical University, Samarkand, Uzbekistan
Email: Osl.A.A@mail.ru
senior lecturer of the course of infectious diseases of FPGE
Uzbekistan, Address: 140100. Republic of Uzbekistan, Samarkand city, st. Amira Temura, house 18.Dilfuza Bahadirovna Fayzullaeva
Republican Center for AIDS Control of Uzbekistan
Email: fayzullaeva.62@mail.ru
Doctor of Medical Sciences, chief physician of the specialized clinic of the AIDS Center
Uzbekistan, Address: Tashkent, 100135 Chilanzar 6-36Zainitdin Sayfutdinovich Kamalov
Republican Center for AIDS Control of Uzbekistan
Email: zay_kamal@rambler.ru
Doctor of Medical Sciences, Professor, Head of the Laboratory of Immunoregulation of the Institute of Human Immunology and Genomics of the Academy of Sciences of the Republic of Uzbekistan
Uzbekistan, Address: 74 Ya. Gulyamova str., Tashkent, 100060Gavhar Abdukarimovna Dushanova
Samarkand State Medical University, Samarkand, Uzbekistan
Author for correspondence.
Email: gavhar_1969@mail.ru
Ph.D, Associate Professor of the Department of Genetics and Biotechnology, Samarkand State University named after Sharof Rashidov
Uzbekistan, Address: 140100, Samarkand, University Boulevard 15References
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