Email this article REALIZATION OF THE ADAPTIVE IMMUNE RESPONSE BY PLASMA CELLS AT THE STAGES OF FORMATION OF POLYPOUS RHINOSINUSITIS
- Authors: Lengina M.A.1, Kryukov A.I.2,3, Korkmazov A.M.1, Kazachkov E.L.1, Medvedeva J.A.1
-
Affiliations:
- South Ural State Medical University of the Ministry of Health of the Russian Federation, Chelyabinsk, Russia
- GBUZ of the city of Moscow "Scientific Research Clinical Institute of Otorhinolaryngology named after L.I. Sverzhevsky" of the Department of Health of the city of Moscow
- The Pirogov Russian National Research Medical University of the Ministry of Health of the Russian Federation
- Section: Immunological readings in Chelyabinsk
- Submitted: 29.03.2025
- Accepted: 25.05.2025
- URL: https://rusimmun.ru/jour/article/view/17179
- DOI: https://doi.org/10.46235/1028-7221-17179-ROT
- ID: 17179
Cite item
Full Text
Abstract
Abstract
The identification of phenotypes/genotypes in the mechanisms of formation of polypous rhinosinusitis made it possible to understand many aspects of the pathophysiological mechanisms of remodeling of the mucous membranes of the nasal cavity and paranasal sinuses, and optimize the choice of effective treatment tactics for patients. At the same time, as authoritative literary sources show, there is a continuing trend towards an increase in the incidence of polypous rhinosinusitis, with frequent relapses accompanied by a significant decrease in quality of life. In this regard, the issues of searching for markers of endotyping of polypous rhinosinusitis remain relevant, which can make it possible to prescribe pathogenetic treatment to the patient at an early stage and ensure the prognosis of the disease.
Aim.To analyze the relative density of immunocompetent lymphocytic cells with morphometric confirmation in patients with polypous rhinosinusitis with immune T2-inflammation.
Materials and methods. The study was conducted with the participation of 22 patients with a verified diagnosis of polypous rhinosinusitis who were hospitalized for elective surgery. All patients were divided into the main group - T2 polypous rhinosinusitis endotype and the control group - Non-T2 polypous rhinosinusitis endotype. Anamnestic, clinical and laboratory data and morphometric criteria of both groups are analyzed.
Results and discussion. In the patients of the main group, there was a tendency to a clear increase in the level of the absolute number of eosinophils in the blood and ranged from 320 to 1512 cells/ml. The analysis of anamnestic data revealed in the patients of the main group an increase in the frequency of re-operations of 21.4% compared to the control group of 12.5%. A high disease history of 29 years and a long relapse of up to 27.5 years was noted in the control group, while in the main group, against the background of a shorter course of polypous rhinosinusitis of 18.2 years, the duration of relapse was more than 4 times shorter compared to the time period of relapses in the control group and was only 6 years. Morphometrically, in the intraoperatively taken polyp tissue, it was found that the relative density of plasmocytes in the inflammatory infiltrate of the polyp stroma in patients in the main group was higher than in the control group and amounted to 0.06 and 0.04 cells per 1 mm2, respectively.
Conclusion. The search for pathogenetic markers of morphometric features and immunological aspects of the formation of a specific immune response in patients with polypous rhinosinusitis will make it possible to prescribe effective treatment to the patient and predict the outcome of the disease.
Keywords
About the authors
Maria Alexandrovna Lengina
South Ural State Medical University of the Ministry of Health of the Russian Federation, Chelyabinsk, Russia
Email: korkmazov74@gmail.com
andidate of medical sciences, associate professor of the Department of Otorhinolaryngology
Russian FederationAndrey Ivanovich Kryukov
GBUZ of the city of Moscow "Scientific Research Clinical Institute of Otorhinolaryngology named after L.I. Sverzhevsky" of the Department of Health of the city of Moscow;The Pirogov Russian National Research Medical University of the Ministry of Health of the Russian Federation
Email: KryukovAI1@zdrav.mos.ru
MD, Professor, Corresponding Member of the Russian Academy of Sciences, Director of the Sverzhevsky Scientific Research Clinical Institute of Otorhinolaryngology of the Moscow Department of Health; Head of the Department of Otorhinolaryngology of the Pirogov Russian National Research Medical University of the Ministry of Health of the Russian Federation
Russian FederationArsen Musosovich Korkmazov
South Ural State Medical University of the Ministry of Health of the Russian Federation, Chelyabinsk, Russia
Email: Korkmazov09@gmail.com
Ph.D. of Medical Sciences, associate professor of the Department of Otorhinolaryngology
Russian FederationEvgeny Leonidovich Kazachkov
South Ural State Medical University of the Ministry of Health of the Russian Federation, Chelyabinsk, Russia
Email: doctorkel@yandex.ru
Dr. Sci. (Med.), Professor, Head of the Department of Pathological Anatomy
Russian FederationJulia Alekseevna Medvedeva
South Ural State Medical University of the Ministry of Health of the Russian Federation, Chelyabinsk, Russia
Author for correspondence.
Email: uamedvedeva@mail.ru
Cand. Sci. (Med.), Associate Professor, Associate Professor Department of Pathological Anatomy
Russian FederationReferences
- Korkmazov M.Yu., Kornova N.V., Lengina M.A., Smirnov A.A., Korkmazov A.M., Dubinets I.D. Effective antibiotic therapy for community-acquired otorhinolaryngological respiratory infection (clinical description). Meditsinskiy sovet = Medical Council, 2022, no. 20, pp. 73-81. (In Russ.)
- Korkmazov M.Y., Lengina M.A., Korkmazov A.M., Kravchenko A.Y. Effect of post-COVID syndrome on the quality of life of patients with allergic rhinitis and eosinophilic phenotype of chronic polyposis rhinosinusitis. Rossiyskiy meditsinskiy zhurnal = Russian Medicine, 2023, Vol. 29, no. 4, pp. 277-290. (In Russ.)
- Korkmazov M.Yu., Zyryanova K.S., Beloshangin A.S. Evaluation of the clinical efficacy of a phytotherapeutic drug in the treatment and prevention of recurring acute rhinosinusitis in children of Chelyabinsk. Meditsinskiy sovet = Medical Council, 2016, no.7, pp.90-93. (In Russ.)
- Korkmazov M.Yu., Yastremsky A.P., Kornova N.V., Lengina M.A., Korkmazov A.M. Therapeutic and diagnostic approaches in the treatment of chronic tonsillitis. Meditsinskiy sovet = Medical Council. 2022. No. 20.90-99. (In Russ.)
- Korkmazov M.Yu., Kazachkov E.L., Lengina M.A., Dubinets I.D., Korkmazov A.M. Cause-effect factors of rhinosinusitis poliposa development. Russian Rhinology. 2023;31(2):124‑130. (In Russ.)
- Korkmazov M. Yu., Angelovich M. S., Lengina M. A., Belousov S. Y. Clinical case of angiosarcoma of the latticed labyrinth and frontal sinus, issues of morphological verification of diagnosis. Bulletin of otorhinolaryngology. 2022. Vol. 87, No. 4. pp. 102-106. (In Russ.)
- Lazareva, A.M., Smirnova O. V. Immunological features of various phenotypes of chronic rhinosinusitis. Medical immunology. 2025. Vol. 27, No. 2. pp. 275-286. (In Russ.)
- Polypous rhinosinusitis. Clinical recommendations. 2019. [Electronic resource]. Acсess mode: https://www.vodkb.ru/ wp-content/uploads/pages/documents/klin-recomend/Polipoznyj-rinosinusit19.pdf. (In Russ.)
- Polypous rhinosinusitis. ID:890_1. Age category: Adults: Clinical recommendations / I. A. Kim, E. V. Nosulya, S. V. Ryazantsev [et al.]. – Moscow: Without publishing house, 2024. – 37 p. (In Russ.)
- Fokkens W.J., Lund V.J., Hopkins C., Hellings P.W., Kern R., Reitsma S., Toppila-Salmi S., Bernal Sprekelsen M., Mullol J. Executive summary of EPOS 2020 including integrated care pathways. Rhinology, 2020, Vol. 58, no. 2, pp. 82-111.
- Halderman A., Lane AP.Genetic and Immune Dysregulation in Chronic Rhinosinusitis // Otolaryngol Clin North Am. 2017 Feb;50(1):13-28.
- Ho J., Bailey M., Zaunders J., Mrad N., Sacks R., Sewell W., Harvey RJ.Group 2 innate lymphoid cells (ILC2s) are increased in chronic rhinosinusitis with nasal polyps or eosinophilia // Clin Exp Allergy. 2015 Feb;45(2):394-403.
- Lund VJ, Kennedy DW. Quantification for staging sinusitis. The Staging and Therapy Group // Ann Otol Rhinol Laryngol Suppl. 1995 Oct; 167:17-21
- Lund V, Mackay I.S. Staging in chronic rhinosinusitis // Rhinology 1993. № 31: 183-184.
- Pan L, Liu Z. Classification of chronic rhinosinusitis with nasal polyps based on eosinophilic inflammation // Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2019 Mar 7;54(3):222-226.
Supplementary files
СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).