STATE OF IMMUNE HOMEOSTASIS IN HYDROGRAPHERS OF THE NORTHERN FLEET OF THE RUSSIAN FEDERATION, CONSIDERING THEIR WORK EXPERIENCE



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Abstract

Abstract

Professional activity and the exposure duration to factors associated with the professional type and work experience influence the modulation of physiological and psychological functions in the human body. The ecological and climatic characteristics of high latitudes, such as, low temperatures, UV index, and variations in photoperiod, exacerbate the effects of professional activity. This complex interplay of professional and environmental factors imposes stress on adaptive capabilities, including those related to the immune system. The purpose of this paper is to identify the impact of job experience on the state of immune homeostasis in hydrographers of the Northern Fleet of the Russia. Sixty-four practically healthy men working in the northern seas were examined based on their length of service: 1. 2.3±0.4 years; 2. 9.0±0.5 years; 3. 15.9±0.6 years; 4. 28.9±1.0 years. The count of lymphocytes with the markers CD5+, CD10+, CD95+, CD71+ and the ratios of their concentrations (CD10+/CD95+ and CD71+/CD95+) were determined in the peripheral blood using the indirect immunoperoxidase reaction method with monoclonal antibodies on dried drop lymphocyte preparations. The analysis showed that the lymphocytes expressing the marker CD5+ decreases in individuals with work experience up to 9.0±0.5 years. The ratios of cell content (CD10+/CD95+ and CD71+/CD95+) are within the optimal balanced values (0.94-1.06) at the norm (1 ± 0.05), with no statistically significant difference based on length of work experience. It was found that the proposed mechanism of immune adaptation in hydrographers is implemented in two ways: in younger hydrographers (with short and medium work experience) through the maintenance of the ratio of lymphoproliferation processes to apoptosis due to (CD10+/CD95+) against the background of a decrease in the level of expression of the marker CD5+; and in older hydrographers (with significant and long-term work experience) through the restoration of the level of expression of the marker CD5+ against the background of an expanded distribution range of the values of CD10+/CD95+ ratio while maintaining the ratio of CD71+/CD95+ within strict limits. The results underscore the necessity for individualized medical and biological monitoring to restore immune homeostasis in the working population residing in high latitudes.

About the authors

Mohammad Sohib Kabbani

N. Laverov Federal Center for Integrated Arctic Research of the Ural Branch of the Russian Academy of Sciences (FECIAR UrB RAS)

Author for correspondence.
Email: sohibmsk@hotmail.com
ORCID iD: 0000-0002-2330-7123
SPIN-code: 7840-2899
Scopus Author ID: 57209616875

Candidate of Biological Sciences, researcher, Laboratory of Physiology of Immunocompetent Cells

Russian Federation, 163000, Russia, Arkhangelsk, avenue Lomonosova 249, office 11.

Lyubov Stanislavovna Shchegoleva

N. Laverov Federal Center for Integrated Arctic Research of the Ural Branch of the Russian Academy of Sciences (FECIAR UrB RAS)

Email: shchegoleva60@mail.ru
ORCID iD: 0000-0003-4900-4021
SPIN-code: 6859-2123
Scopus Author ID: 6603940197

Doctor of Biological Sciences, Professor, Chief Researcher, head of laboratory of Physiology of Immunocompetent Cells

Russian Federation, 163000, Russia, Arkhangelsk, avenue Lomonosova 249, office 11.

Elizaveta Yurievna Shashkova

N. Laverov Federal Center for Integrated Arctic Research of the Ural Branch of the Russian Academy of Sciences (FECIAR UrB RAS)

Email: eli1255@yandex.ru
ORCID iD: 0000-0002-1735-6690
SPIN-code: 8137-0571
Scopus Author ID: 7196280031

Candidate of Biological Sciences, senior researcher, Laboratory of Physiology of Immunocompetent Cells

Russian Federation, 163000, Russia, Arkhangelsk, avenue Lomonosova 249, office 11.

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Copyright (c) Kabbani M.S., Shchegoleva L.S., Shashkova E.Y.

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