Email this article MODULATING EFFECT OF EUKARYOTIC DNA ON THE EXPRESSION OF FUNCTIONALLY IMPORTANT RECEPTOR OF NEUTROPHILIC GRANULOCYTES
- Authors: Rusinova T.V.1, Chudilova G.A.1, Kovaleva S.V.1, Tarakanov V.A.1, Barova N.K.1, Nesterova I.V.1,2
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Affiliations:
- Federal State Budget Educational Institution of Higher Education «Kuban State Medical University» of the Ministry of Health Care of Russia
- Federal State Autonomous Budget Educational Institution of Higher Professional Education «Peoples’ Friendship University of Russia» of Ministry of Education and Science of Russia
- Issue: Vol 22, No 2-1 (2019)
- Pages: 503-505
- Section: ORIGINAL ARTICLES
- Submitted: 13.05.2020
- Accepted: 13.05.2020
- Published: 15.04.2019
- URL: https://rusimmun.ru/jour/article/view/197
- DOI: https://doi.org/10.31857/S102872210006945-4
- ID: 197
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Abstract
In article were studied phenotypic features of 2 neutrophilic granulocytes (NG) subsets expressing CD64, CD32, CD16, CD11b in children with systemic purulent-inflammatory diseases. We evaluated sodium salt of eukaryotic DNA effect on transformed phenotype of these NG subsets in vitro. Immunomodulatory effects of DNA have been established, which are manifested in a significant decrease in the number of NGs of the pro-inflammatory subset CD64+CD32+CD16+CD11b+NG, the decrease in the number of NG subset of CD64+CD32–CD16+CD11b+ NG defective in CD32 and the increase the antiinflammatory subset CD64+CD32+CD16+CD11b+NG.
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About the authors
T. V. Rusinova
Federal State Budget Educational Institution of Higher Education «Kuban State Medical University» of the Ministry of Health Care of Russia
Email: fake@neicon.ru
Ph.D. (Biological Sciences), Researcher, Central Research Laboratory,
Krasnodar
Russian FederationG. A. Chudilova
Federal State Budget Educational Institution of Higher Education «Kuban State Medical University» of the Ministry of Health Care of Russia
Email: fake@neicon.ru
PhD (Biological Sciences), Associate Professor, Head of Department of Clinical and Experimental Immunology and Molecular Biology of Central Research Laboratory,
Krasnodar
Russian FederationS. V. Kovaleva
Federal State Budget Educational Institution of Higher Education «Kuban State Medical University» of the Ministry of Health Care of Russia
Email: fake@neicon.ru
Ph.D. (Medical Science), Associate Professor, Senior Researcher, Central Research Laboratory,
Krasnodar
Russian FederationV. A. Tarakanov
Federal State Budget Educational Institution of Higher Education «Kuban State Medical University» of the Ministry of Health Care of Russia
Email: fake@neicon.ru
Doctor of Medical Sciences (MD), Professor, Head of the Department of Surgical Diseases of Childhood,
Krasnodar
Russian FederationN. K. Barova
Federal State Budget Educational Institution of Higher Education «Kuban State Medical University» of the Ministry of Health Care of Russia
Email: fake@neicon.ru
PhD (Medical Science), Assistant of the Department of Surgical Diseases of Childhood,
Krasnodar
Russian FederationI. V. Nesterova
Federal State Budget Educational Institution of Higher Education «Kuban State Medical University» of the Ministry of Health Care of Russia;Federal State Autonomous Budget Educational Institution of Higher Professional Education «Peoples’ Friendship University of Russia» of Ministry of Education and Science of Russia
Author for correspondence.
Email: inesterova1@yandex.ru
Chief Researcher of Central Research Laboratory, Krasnodar;
Doctor of Medical Sciences (MD), Professor, Professor of the Department of Allergology and Immunology, Moscow
Russian FederationReferences
- Нестерова И.В., Колесникова Н. В., Чудилова Г. А., Ломтатидзе Л. В., Ковалева С. В., Евглевский А. А., Нгуен Т. З. Л. Новый взгляд на нейтрофильные гранулоциты: переосмысление старых догм. (Часть 2). Инфекция и иммунитет 2018, 8(1), 7–18. doi: 10.15789/2220-7619-2018-1-7-18.
- García-Salido A., de Azagra-Garde A.M., García-Teresa M. A. Accuracy of CD64 expression on neutrophils and monocytes in bacterial infection diagnosis at pediatric intensive care admission. Eur J Clin Microbiol Infect Dis. 2019, 1–7. doi: 10.1007/s00005–017–0476–4.
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