Email this article DETERMINATION OF THE LEVEL OF CYTOKINES IN BRONCHOALVEOLAR LAVAGE FLUID IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONAY DISEASE
- Authors: Ryabova L.V.1, Nikonova S.E.2
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Affiliations:
- Federal state budgetary educational institution of higher education “South Ural State Medical University”
- Municipal Autonomous Healthcare Institution of the Order of the Red Banner of Labor “City Clinical Hospital No. 1”
- Issue: Vol 22, No 2-1 (2019)
- Pages: 506-508
- Section: ORIGINAL ARTICLES
- Submitted: 13.05.2020
- Accepted: 13.05.2020
- Published: 15.04.2019
- URL: https://rusimmun.ru/jour/article/view/198
- DOI: https://doi.org/10.31857/S102872210006946-5
- ID: 198
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Abstract
19 patients were diagnosed with stage III–IV COPD, the smoking experience was 39.1±1.94 years. In this group of patients, a study of cytokines IL-1β, IL-6, IL-8, IL-10, TNF-α in bronchoalveolar lavage fluid was carried out by the method of enzyme-linked immunosorbent assay. Disequilibrium of cytokins was found, which was appeared by statistically significant raising of proinfl ammatory cytokines IL-1β, IL-6, IL-8, and statistically significant lowering for anti-inflammatory cytokines IL-10, so that proves presence of chronic persistent infl ammations in the bronchial tree.
About the authors
L. V. Ryabova
Federal state budgetary educational institution of higher education “South Ural State Medical University”
Author for correspondence.
Email: fake@neicon.ru
holder of Habilitation degree in medicine, professor of Propaedeutics of Internal Diseases,
Chelyabinsk
Russian FederationS. E. Nikonova
Municipal Autonomous Healthcare Institution of the Order of the Red Banner of Labor “City Clinical Hospital No. 1”
Email: nikonova_se@mail.ru
Head of the Pneumology Department,
Chelyabinsk
Russian FederationReferences
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Supplementary files
СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).