Email this article ANTI-TUMOR AND IMMUNOMODULATING EFFECTS OF RECOMBINANT HUMAN TUMOR NECROSIS FACTOR ALPHA IN A DELIVERY SYSTEMIN B16-F10 MELANOMA MICE
- Authors: Sysoeva G.M.1, Ryabchikova E.I.2, Gamaley S.G.1, Lebedev L.R.1, Volosnikova E.A.1, Danilenko E.D.1
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Affiliations:
- Institute of Medical Biotechnology FBRI SRC VB «Vector» Rospotrebnadzor
- Institute of Chemical Biology and Fundamental Medicine SB RAS
- Issue: Vol 22, No 2-1 (2019)
- Pages: 575-577
- Section: ORIGINAL ARTICLES
- URL: https://rusimmun.ru/jour/article/view/221
- DOI: https://doi.org/10.31857/S102872210006979-1
- ID: 221
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Abstract
It was established that recombinant human tumor necrosis factor alpha in a delivery system has pronounced antitumor and immunomodulating effects in murine B16-F10 melanoma model. The preparation significantly inhibited the growth of experimental tumor (TGI 60%), increased tumor infiltration by immune system cells (CD3+, CD11b+) and increased the activity of immunocompetent cells mediating antitumor response.
About the authors
G. M. Sysoeva
Institute of Medical Biotechnology FBRI SRC VB «Vector» Rospotrebnadzor
Author for correspondence.
Email: sysoeva_gm@vector.nsc.ru
SRF, Institute of Medical Biotechnology,
Berdsk, Novosibirsk Region
Russian FederationE. I. Ryabchikova
Institute of Chemical Biology and Fundamental Medicine SB RAS
Email: fake@neicon.ru
Institute of Chemical Biology and Fundamental Medicine,
Berdsk, Novosibirsk Region
Russian FederationS. G. Gamaley
Institute of Medical Biotechnology FBRI SRC VB «Vector» Rospotrebnadzor
Email: fake@neicon.ru
Head of Department of Biological Research,
Berdsk, Novosibirsk Region
Russian FederationL. R. Lebedev
Institute of Medical Biotechnology FBRI SRC VB «Vector» Rospotrebnadzor
Email: fake@neicon.ru
Dr. habil., Head of the laboratory of Nucleic Acids and Recombinant Proteins,
Berdsk, Novosibirsk Region
Russian FederationE. A. Volosnikova
Institute of Medical Biotechnology FBRI SRC VB «Vector» Rospotrebnadzor
Email: fake@neicon.ru
PhD, Head of Laboratory of Obtaining and Analysis of Bio substances,
Berdsk, Novosibirsk Region
Russian FederationE. D. Danilenko
Institute of Medical Biotechnology FBRI SRC VB «Vector» Rospotrebnadzor
Email: fake@neicon.ru
PhD, director, Institute of Medical Biotechnology,
Berdsk, Novosibirsk Region
Russian FederationReferences
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