HIV INFECTION AND HIV/HCV CO-INFECTION PROBLEM

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Abstract

The patterns of coinfection, which extend to coinfection of HIV/HCV, make it expedient to test the hypothesis about the impact of the order of viral pathogens admission into host for the development of the infectious process. It was found that this factor has a significant impact on the course of liver fibrosis, the viral load of HIV and HCV, the state of the immune response. In cases where HIV infection develops before hepatitis C virus infection, liver fibrosis often takes a progressive course, the viral load of HIV is reduced, and HCV load increases, CD8+ T-lymphocytes and immunoregulatory index values become lower.

About the authors

I. P. Balmasova

A.I. Evdokimov Moscow Univercity of Medcine & Dentistry;
Peoples‘ Friendship University of Russia

Author for correspondence.
Email: iri.balm@mail.ru

MD, professor, Head of the Laboratory of the Pathogenesis and Treatment of Infectious Diseases;

Professor of Allergology and Immunology Department,

Moscow

Russian Federation

E. S. Malova

Peoples‘ Friendship University of Russia

Email: fake@neicon.ru

MD, Professor of Allergology and Immunology Department,

Moscow 

Russian Federation

E. P. Efratova

Samara State Medical University

Email: fake@neicon.ru

ordinator of Infectious Diseases Department,

Samara

Russian Federation

References

  1. Bonora S., Puoti M. Use of daclatasvir in HCV/HIVcoinfected patients in a real-life setting. AIDS Rev. 2017, 19(1), 24–34.
  2. Павлов Д. В., Шатрова Д. Х., Галиуллин Н. И., Нагимова Ф. И. Особенности коинфицирования ВИЧ-по зитивных пациентов вирусом гепатита С. Казанский медицинский журнал. 2014, 95(6), 905–908.
  3. Sharma S., Thomas P. G. The two faces of heterologous immunity: protection or immunopathology. J Leukoc Biol. 2014, 95(3), 405–416.
  4. Poynard T., Ratziu V., Benhamou Y., Thabut D., Moussalli J. Biomarkers as a first-line estimate of injury in chronic liver diseases: time for a moratorium on liver biopsy? Gastroenterology. 2005, 128 (4), 1146–1148.
  5. Kumar N., Sharma S., Barua S., Tripathi B. N., Rouse B. T. Virological and Immunological Outcomes of Coinfections. Clin Microbiol Rev. 2018, 31(4), e00111–17.

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Copyright (c) 2019 Balmasova I.P., Malova E.S., Efratova E.P.

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This work is licensed under a Creative Commons Attribution 4.0 International License.

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