EMBRIOGENESIS OF NEURORECEPTOR AND NEUROIMMUNE SYSTEMS OF A HUMAN WITH NEONATAL INFLUENCE OF ALCOHOL ON FETUS

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Abstract

Alcohol and tissue hypoxia in the early stages of embryonic development has a modifying effect on the formation of the neuroimmune and neurotransmitter systems of the developing brain: microglia, the GABA receptor system, their functional and mediator activity.

About the authors

T. V. Shushpanova

Mental Health Research Institute“Tomsk Scientific ResearchMedical Center of Russian Academy of Sciences”, Tomsk

Author for correspondence.
Email: mental@tnimc.ru

PhD, M.D., Leading Researcher, Laboratory of Clinical Psychoneuroimmunology and Neurobiology,

Tomsk

Russian Federation

A. V. Solonsky

Mental Health Research Institute“Tomsk Scientific ResearchMedical Center of Russian Academy of Sciences”

Email: fake@neicon.ru

PhD, M.D., Leading Researcher, Laboratory of Clinical Psychoneuroimmunology and Neurobiology,

Tomsk

Russian Federation

A. S. Kudrenko

State educational institution of higher vocational education “Omsk State Medical Academy of the Federal Agency for Health and Social Development”

Email: fake@neicon.ru

PhD, Doctor of Clinical Laboratory Diagnostics Group of Cytological Screening,

Omsk

Russian Federation

N. A. Bohan

Mental Health Research Institute“Tomsk Scientific ResearchMedical Center of Russian Academy of Sciences”

Email: fake@neicon.ru

PhD, M.D., Academician of RASci., Head of Addictive Department,

Tomsk

Russian Federation

References

  1. Morris S. A., Eaves D. W., Smith A. R, Nixon K. Alcohol inhibition of neurogenesis: A mechanism of hippocampal neurodegeneration in an adolescent alcohol abuse model. Hippocampus. 2010, 20(5), 596–607.
  2. Shushpanova T. V., Solonskii A. V., Shushpanova O. V. Molecular-Cellular Targets of the Pathogenetic Action of Ethanol in the Human Brain in Ontogenesis and the Possibility of Targeted Therapy Aimed at Correcting the Effect of Pathogenic Factors. In: Drug addiction. Edited by F. Zhao, co-edited by M. Li. London, United Kingdom: In tech Open. 2018, 73102. doi: 10.5772/intechopen.73333
  3. Shushpanova T. V., Solonskii A. V., Bokhan N. A. Cortical Synaptogenesis in the Human Brain in Conditions of Prenatal Alcoholization. Autism – Open Access. 2016, 6(2), 173–179. doi: 10.4172/2165-7890.1000173
  4. Сепиашвили Р. И. Иммунная система мозга и спинномозговой жидкости. Аллергология и иммунология. 2016, 16(1), 26–38.
  5. Андросова Л. В., Симашкова Н. В., Шушпанова О. В., Отман И. Н., Клюшник Т. П. Возможности использования некоторых иммунологических показателей для оценки тяжести клинического состояния пациентов с начавшейся в детском возрасте шизофренией. Журналне врологии и психиатрии им. С. С. Корсакова. 2016, 2, 85–89.

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Copyright (c) 2019 Shushpanova T.V., Solonsky A.V., Kudrenko A.S., Bohan N.A.

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