INFLUENCE OF THE LEVELS OF THE PRO-INFLAMMATORY CYTOKINES ON THE FORMATION OF EXTRACELLULAR NEUTROPHILIC TRAPS IN DISSEMINATED OVARIAN CANCER

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Abstract

The eff ect of IL-8 and IL-18 o the ability of circulating neutrophils to form extracellular traps (NET), contributing to the proliferation and metastasis of tumor cells, is shown. The aim of the study was to evaluate the eff ect of IL-8 and IL-18 in serum on the formation of NETs in advanced ovarian cancer. We have found that an increase in the levels of pro-infl ammatory cytokines IL-8 and IL-18 in the dynamics of progression of OC is accompanied by a decrease in the number of NETs and an increase in the index of NET formed by circulating neutrophils, which may indicate a decrease in the killer function of the latter.

About the authors

T. V. Abakumova

Ulyanovsk State University

Author for correspondence.
Email: taty-abakumova@yandex.ru

Ph.D., Associate Professor at the Department of Physiology and Pathophysiology,

Ulyanovsk

Russian Federation

T. P. Gening

Ulyanovsk State University

Email: fake@neicon.ru

Doctor of Biological sciences, Professor, Head of the Department of Physiology and Pathophysiology,

Ulyanovsk

Russian Federation

D. R. Dolgova

Ulyanovsk State University

Email: fake@neicon.ru

Ph.D., Associate Professor at the Department of Physiology and Pathophysiology,

Ulyanovsk

Russian Federation

I. I. Antoneeva

Ulyanovsk State University;
Regional Clinical Oncologic Center

Email: fake@neicon.ru

Doctor of medical sciences, Associate Professor, professor at the department of oncology and radiology;

Head of the gynecological department,

Ulyanovsk

Russian Federation

S. O. Gening

Ulyanovsk State University;
Regional Clinical Oncologic Center

Email: fake@neicon.ru

graduate student at the department of oncology and radiology;

Oncologist of the Department of Chemotherapy of Hemoblastosis and Solid Tumors,

Ulyanovsk

Russian Federation

References

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  2. Medina L., Rabinovich A., Piura B., Dyomin V., Levy R.S., Huleihel M. Expression of IL-18, IL-18 binding protein, and IL-18 receptor by normal and cancerous human ovarian tissues: possible implication of IL-18 in the pathogenesis of ovarian carcinoma. Mediators Inflamm. 2014; 2014:914954. doi: 10.1155/2014/914954.
  3. Yin J., Zeng F., Wu N., Kang K., Yang Z., Yang H. Interleukin-8 promotes human ovariancancer cell migration by epithelial-mesenchymal transition induction in vitro. Clin Transl Oncol. 2015;17(5);365–70. doi: 10.1007/s12094-014-1240-4.
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  5. Garley M., Jabloňská E., Suraźyński A., Grubczak K., Ratajczak-Wrona W., Iwaniuk A., Dabrovska D., Palka J.A., Moniuszko M. CytokineNetwork&NETs. FoliaBiol (Praha). 2017;63(5–6);182–189. 6. Erpenbeck L., Schön M. P. Neutrophil extracellular traps: protagonists of cancer progression? Oncogene. 2017; 36(18); 2483–2490. doi: 10.1038/onc.2016.406.
  6. Долгушин И. И., Шишкова Ю. С., Семенова А. Б., Казачков Е. Л., Важенин А. В., Шаманова А. Ю., Димов Г. П. Взгляд на роль нейтрофильного внеклеточного ДНК, как компонента микроокружения опухоли, в процессах канцерогенеза. Уральский медицинский журнал. 2014, 2(116), 19–22.

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Copyright (c) 2019 Abakumova T.V., Gening T.P., Dolgova D.R., Antoneeva I.I., Gening S.O.

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