CO-EXPRESSION OF RECEPTORS TO THE ALPHA TUMOR NECROSIS FACTOR ALPHA IN T CELL SUBPOPULATIONS IN RHEUMATOID ARTHRITIS

A. A. Alshevskaya; Альшевская А. А.; I. A. Belomestnova; Беломестнова И. А.; J. V. Zhukova; Жукова Ю. В.; O. A. Chumasova; Чумасова О. А.; N. S. Shkaruba; Шкаруба Н. С.; A. E. Sizikov; Сизиков А. Э.; J. A. Sennikova; Сенникова Ю. А.; O. P. Vorobyova; Воробьева О. П.

doi:10.31857/S102872210006764-5

CO-EXPRESSION OF RECEPTORS TO THE ALPHA TUMOR NECROSIS FACTOR ALPHA IN T CELL SUBPOPULATIONS IN RHEUMATOID ARTHRITIS

Authors: Alshevskaya A.A.¹, Belomestnova I.A.¹, Zhukova J.V.¹, Chumasova O.A.¹, Shkaruba N.S.¹, Sizikov A.E.¹, Sennikova J.A.², Vorobyova O.P.¹^,3
Affiliations:
1. Research Institute of Fundamental and Clinical Immunology
2. Novosibirsk State Medical University
3. Novosibirsk National Research State University
Issue: Vol 22, No 2-2 (2019)
Pages: 707-709
Section: ORIGINAL ARTICLES
URL: https://rusimmun.ru/jour/article/view/265
DOI: https://doi.org/10.31857/S102872210006764-5
ID: 265

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Abstract

The tumor necrosis factor alpha (TNFα) play key role as the main pro-infl ammatory cytokine in immune processes in rheumatoid arthritis (RA). However, the activity and functions of TNFα can be regulated not only by soluble receptors (which act primarily as neutralizers of action), but also by the amount, density, and co-expression of its membrane-bound receptors type 1 and 2 (TNFR1 and TNFR2). Analysis of the co-expression parameters of TNFR1 and TNFR2 in RA patients compared with healthy donors showed that changes in the amount and co-expression of type 1 and type 2 receptors for TNF-alpha on the surface of immunocompetent cells are associated with indicators of disease activity.