CYTOKINE LEVEL IN BLOOD SERUM IN PATIENTS WITH ACQUIRED ANGIOEDEMA

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Abstract

Cytokines are biological markers whose overproduction can lead to an inflammatory reaction and cause the development of pathological reactions. In the present work, the serum levels of IL-17A, IL-17F and IL-13 were studied in 36 patients with acquired angioedema during the period of clinical manifestations. The control group consisted of 10 practically healthy donors. This study showed a high level of IL-17A, IL-17F in patients with acquired angioedema during the period of clinical manifestations, while a comparative analysis showed no differences in the content of serum IL-13 in the control group and the control group. Thus, the determination of the level of IL-17A, IL-17 F in serum can be used as a laboratory diagnostic marker of acquired angioedema.

About the authors

A. O. Vlasova

Regional State Budgetary Healthcare Institution «Vladivostok Clinical and Diagnostic Centre»

Author for correspondence.
Email: a.vlasova.vl@gmail.com

аllergist-immunologist, Allergy-Respiratory Center, Vladivostok Clinical Diagnostic Center,

Vladivostok, Primorsky Krai

Russian Federation

References

  1. Кетлинский С.А., Симбирцев А. С. Цитокины. Фолиант, СПб 2008, 9–11.
  2. Arcoleo Francesco, Lo Pizzo Mariangela, Misiano Gabriella, Milano Salvatore, Colonna Romano Giuseppina, MuggeoVito, Cillari Enrico. The complex alteration in the network of IL-17-type cytokines in patients with hereditary angioedema. Clinical and Experimental Medicine August 2018, Volume 18, Issue 3, pp 355–36.
  3. Narges Seyfi zadeh, Nayer Seyfi zadeh, Tohid Gharibi, Zohreh Babaloo. Interleukin-13 as an important cytokine: A review on its roles in some human diseases. Acta Microbiol Immunol Hung. 2015 Dec;62(4): 341–78.

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