IMMUNE DISORDERS AND ARTERIAL PRESSURE PATIENTS WITH ARTERIAL HYPERTENSION

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Abstract

The study included 68 patients with arterial hypertension 1, 2 and 3 degrees, in whom the concentration of cytokines and components of the complement system was determined in the blood plasma before and after 4 weeks of systemic antihypertensive therapy. In patients with arterial hypertension prior to the onset of systemic antihypertensive therapy, changes in the level of pro-inflammatory and antiinflammatory cytokines and activation of the complement system were found in proportion to the level of blood pressure. In patients with arterial hypertension who have reached the target values of blood pressure against the background of ongoing pharmacotherapy, the severity of immune changes is significantly lower than in patients whose blood pressure has not reached the target level.

About the authors

E. V. Gavrilyuk

Kursk State Medical University

Author for correspondence.
Email: ganneta@list.ru

PhD, Assistant of the Department of Internal Diseases № 2,

Kursk

Russian Federation

A. I. Konoplya

Kursk State Medical University

Email: fake@neicon.ru

MD, Professor, Head of the Department of Biological Chemistry,

Kursk

Russian Federation

V. P. Mikhin

Kursk State Medical University

Email: fake@neicon.ru

MD, Professor, Head of the Department of Internal Diseases № 2,

Kursk

Russian Federation

Y. V. Prokofieva

Kursk State Medical University

Email: fake@neicon.ru

PhD, Assistant of the Department of Internal Medicine Propaedeutic,

Kursk

Russian Federation

L. N. Serikova

Kursk State Medical University

Email: fake@neicon.ru

PhD, Associate Professor of the Department of Internal Medicine Propaedeutic,

Kursk

Russian Federation

References

  1. Уклистая Т. А., Полунина О. С., Полунина Е. А., Севостьянова И. В. Анализ взаимосвязи показателей суточного мониторирования артериального давления с маркерами воспаления и оксидативного стресса при сочетанной кардиореспираторной патологии. Курский научно-практический вестник «Человек и его здоровье», 2017, 4, 12–18.
  2. Гаврилюк Е. В., Конопля А. И., Караулов А. В. Роль иммунных нарушений в патогенезе артериальной гипертонии. Иммунология, 2016, 37 (1), 29–34

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Copyright (c) 2019 Gavrilyuk E.V., Konoplya A.I., Mikhin V.P., Prokofieva Y.V., Serikova L.N.

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This work is licensed under a Creative Commons Attribution 4.0 International License.

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