IMMUNE MODULATING EFFECTS OF MYELOPEPTIDES MP-5 AND MP-6 UNDER THE STRESS CONDITIONS

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Abstract

The myelopeptides MP-5 and MP-6 are capable of correcting changes in the production of reactive oxygen species and cytokines (IL-1β and IL-10) by peritoneal macrophages under stress.

About the authors

O. N. Gein

FGBOU VO Perm State Pharmaceutical Academy, Ministry of Health of the Russian Federation

Author for correspondence.
Email: fake@neicon.ru

сandidate of Biological Sciences, Associate Professor of the Department of Pharmacology,

Perm

Russian Federation

T. V. Gavrilova

Institute of Ecology and Genetics of Microorganisms, Ural Branch of the Russian Academy of Sciences;
FSBEI HE «Academician E. A. Wagner Perm State Medical University» of the Ministry of Healthcare of the Russian Federation

Email: fake@neicon.ru

MD, professor, leading researcher of the institute of ecology and genetics of microorganisms, ural branch of the russian academy of sciences, Head of the Department,

Perm

Russian Federation

Ya. A. Kadochnikova

Perm State Research University Perm State Medical University

Email: fake@neicon.ru

a student of the Biology Faculty,

Perm

Russian Federation

M. V. Chereshneva

FGBUN Institute of Immunology and Physiology, Ural Branch of the Russian Academy of Sciences

Email: fake@neicon.ru

MD, Professor, Research Fellow,

Ekaterinburg

Russian Federation

V. A. Chereshnev

FGBUN Institute of Immunology and Physiology, Ural Branch of the Russian Academy of Sciences

Email: fake@neicon.ru

Academician of the Russian Academy of Sciences, MD, Chief Researcher,

Ekaterinburg

Russian Federation

References

  1. Гейн С. В., Гаврилова Т. В., Журавлёва Л. С., Черешнева М. В., Кирилина Е.А, Черешнев В. А. // Доклады Академии наук. 2014. 455(2). 232–234.
  2. Гейн С. В., Гаврилова Т. В., Черешнев В. А., Черешнева М. В. // Цитокины и воспаление. 2008. 7(1). 24–28.
  3. Петров Р. В., Михайлова А. А., Фонина Л. А., Степаненко Р. Н. Миелопептиды. – М.: Наука, 2000. 181 с.
  4. Руднева Т. Б., Осипова Е. Ю., Махайлова А. А., Манько В. М. Коррекция миелопептидами дифференцировки кроветворных клеток-предшественников у мышей с экспериментальным Т-иммунодефицитом // Бюллетень экспериментальной биологии и медицины. – 1989. – Т. 107,№ 6. – с. 718–720.

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Copyright (c) 2019 Gein O.N., Gavrilova T.V., Kadochnikova Y.A., Chereshneva M.V., Chereshnev V.A.

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