INFLUENCE OF 1, 3, 4-TIADIAZINE GROUP COMPOUNDS ON LEUKOCYTE FRACTIONS OF TYPE2 DIABETIC RATS

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Abstract

The injections of two compounds of the substituted 1, 3, 4-thiadiazines class (L-17 and L-14) were accompanied by normalization of the total number and fractions of peripheral blood leukocytes in rats with type 2 diabetes, obtained by administration of nicotinamide and streptozotocin. L-17 is more effective than L-14 in reducing hyperglycemia.

About the authors

V. V. Emelyanov

Ural Federal University named after the first president of Russia B. N. Yeltsin

Email: i.goette@yandex.ru

PhD, Associate Professor, Department of Medical Biochemistry and Biophysics,

 

Russian Federation

S. A. Brilliant

Institute of Immunology and Physiology UB RAS

Email: fake@neicon.ru

junior researcher, laboratorY of immunophysiology and immunopharmacology IIF UB RAS,

researcher, GUZ SO IMKT,

Yekaterinburg

Russian Federation

I. F. Gette

Ural Federal University named after the first president of Russia B. N. Yeltsin;
Institute of Immunology and Physiology UB RAS

Author for correspondence.
Email: fake@neicon.ru

senior researcher Department of Immunochemistry;

Ph.D., senior researcher, laboratory of morphology and biochemistry,

Yekaterinburg

Russian Federation

I. G. Danilova

Ural Federal University named after the first president of Russia B. N. Yeltsin;
Institute of Immunology and Physiology UB RAS

Email: fake@neicon.ru

Head of the Department of medical biochemistry and biophysics,

MD, Associate Professor, Head of the Laboratory of Morphology and Biochemistry,

Yekaterinburg

Russian Federation

L. P. Sidorova

Ural Federal University named after the first president of Russia B. N. Yeltsin

Email: fake@neicon.ru

Ph.D.,

Yekaterinburg

Russian Federation

T. A. Tseitler

Ural Federal University named after the first president of Russia B. N. Yeltsin

Email: fake@neicon.ru

associate professor of the Department of Organic and Biomolecular Chemistry, 

Yekaterinburg

Russian Federation

References

  1. Akbari M., Hassan-Zadeh V. Hyperglycemia Affects the Expression of Inflammatory Genes in Peripheral Blood Mononuclear Cells of Patients with Type 2 Diabetes. Immunol Invest. 2018; 47(7), 654–665.
  2. Mineoka Y., Ishii M., Hashimoto Y., Nakamura N., Katsumi Y., Isono M., Fukui M. Neutrophil-lymphocyte ratio correlates with limited joint mobility of hand in patients with type 2 diabetes. Endocr J. 2018; 65(10), 1011–1017.
  3. Емельянов В. В., Саватеева Е. А., Сидорова Л. П., Цейтлер Т. А., Гетте И. Ф., Булавинцева Т. С., Смирных С. Е., Максимова Н. Е. 2-Морфолино-5- фенил-6Н-1,3,4-тиа диазин корригирует метаболические нарушения при формировании аллоксанового сахарного диабета у крыс// Бюллетень экспериментальной биологии и медицины. 2016. Т. 162, № 7. С. 42–45.
  4. Емельянов В. В., Бриллиант С. А., Гетте И. Ф., Данилова И. Г., Клюева Ю. Н., Сидорова Л. П., Цейтлер Т. А. Влияние соединения 2-морфолино-5- фенил-6н-1,3,4-тиадиазин гидробромида на изменение гематологических показателей крыс с аллоксановым диабетом // Российский иммунологический журнал. 2018. Т. 12(21), № 3. С. 276-280.
  5. Спасов А. А., Воронкова М. П., Сингур Г. Л., Чепляева Н. И., Чепурнова М. В. Экспериментальная модель сахарного диабета типа 2 // Биомедицина. 2011, № 3. С. 12–18.

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Copyright (c) 2019 Emelyanov V.V., Brilliant S.A., Gette I.F., Danilova I.G., Sidorova L.P., Tseitler T.A.

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