DEVELOPMENT OF MODELS OF HUMAN MALIGNANT TUMORS FOR CELLULAR IMMUNOTHERAPY

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Abstract

Development of ectopic and orthotopic models of human malignant tumors in nude mice with consequent morphologic and immunologic studies was carried out. Morphologic compliancy of tumors having grown in mice to the initial ones was shown. Divergent immunologic changes were found in animals with ectopic and orthotopic tumors.

About the authors

E. Y. Zlatnik

Federal Budget Institution Rostov Research Institute of Oncology

Author for correspondence.
Email: elena-zlatnik@mail.ru

MD, Prof., Chief Researcher, Laboratory of Immunophenotyping of Tumors,

Rostov-on-Don

Russian Federation

A. Yu. Maksimov

Federal Budget Institution Rostov Research Institute of Oncology

Email: fake@neicon.ru

MD., Professor, Deputy General Director for Advanced Scientific Developments,

Rostov-on-Don

Russian Federation

A. S. Goncharova

Federal Budget Institution Rostov Research Institute of Oncology

Email: fake@neicon.ru

Ph D., Head of Experimental Laboratory Center,

Rostov-on-Don

Russian Federation

N. S. Karnaukhov

Federal Budget Institution Rostov Research Institute of Oncology

Email: fake@neicon.ru

Ph D., Head of Department of Pathological Anatomy,

Rostov-on-Don

Russian Federation

References

  1. Трещалина Е. М. Иммунодефицитные мыши Balb/c Nude и моделирование различных вариантов опухолевого роста для доклинических исследований // Российский биотерапевтический журнал. – 2017. – Т. 16. – № . 3 – С. 6–13. doi: 10.17650/1726-9784-2017-16-3-6-13.
  2. Zhao X., Li L., Starr T. K., Subramanian S. Tumor location impacts immune response in mouse models of colon cancer. Oncotarget, 2017; 8(33): 54775–54787. doi: 10.18632/oncotarget.18423.
  3. Karasova D., Sebkova A., Havlickova H., Sisak F., Volf J., Faldyna M., Ondrackova P., Kummer V., Rychlik I. Influence of 5 major Salmonella pathogenicity islands on NK cell depletion in mice infected with Salmonella enterica serovar Enteritidis. BMC Microbiol., 2010; 10: 75. Published online 2010 Mar 12 doi: 10.1186/1471-2180-10-75.

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Copyright (c) 2019 Zlatnik E.Y., Maksimov A.Y., Goncharova A.S., Karnaukhov N.S.

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This work is licensed under a Creative Commons Attribution 4.0 International License.
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