Email this article CINETIDINE – CYTOKINES, ANTIBACTERIAL AND ANTIVIRAL ACTIVITY
- Authors: Zurochka V.A.1,2, Zurochka A.V.1,2, Fomina L.O.1, Dobrynina M.A.1, Zabkov O.I.1, Gritsenko V.A.3
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Affiliations:
- Institute of Immunology and Physiology UrB RAS
- South-Ural State University (National Research University)
- Institute of Cellular and Intracellular Symbiosis UrB RAS
- Issue: Vol 22, No 2-2 (2019)
- Pages: 781-783
- Section: ORIGINAL ARTICLES
- Submitted: 03.06.2020
- Accepted: 03.06.2020
- Published: 15.07.2019
- URL: https://rusimmun.ru/jour/article/view/299
- DOI: https://doi.org/10.31857/S102872210006700-5
- ID: 299
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Abstract
Purpose. To analyze the nature of the influence of the synthetic peptide of the active center of granulocyte-macrophage colony stimulating factor (GM-KSF) – ZP2 on the growth in the liquid nutrient medium and biofilm formation of Museum and clinical strains of bacteria, antiviral activity in vitro and in vivo.
Results. It was shown that the peptide of the active center GM-KSF has a pronounced antibacterial effect on a wide range of gram-positive and gram-negative bacteria, reducing the growth of biofilm formation and biomass of bacteria, and the created cosmetic drug ACEGRAM has a similar effect. At the same time sredstva has a strong antiviral dacvim against DNA- and RNA-containing viruses in vitro and in vivo.
Conclusion. Created with synthetic peptide cosmetics Acegram spray and gel have strong antibacterial and antiviral properties in vivo and can be recommended for the treatment of lesions of skin and mucous bacteria and viruses and the peptide that generated the funds is in their mechanisms of action and properties of classical kinocidinum.
About the authors
V. A. Zurochka
Institute of Immunology and Physiology UrB RAS;South-Ural State University (National Research University)
Author for correspondence.
Email: v_zurochka@mail.ru
MD, senior scientific researcherof the laboratory of immunology of inflammation;
professor of the Department of food and biotechnology,
Chelyabinsk
Russian FederationA. V. Zurochka
Institute of Immunology and Physiology UrB RAS;South-Ural State University (National Research University)
Email: fake@neicon.ru
MD, professor, leader researcher of the laboratory of immunology of inflammation;
professor of the Department of food and biotechnology,
Chelyabinsk
Russian FederationL. O. Fomina
Institute of Immunology and Physiology UrB RAS
Email: fake@neicon.ru
post-graduate student of the Institute of immunology and physiology,
Ekaterinburg
Russian FederationM. A. Dobrynina
Institute of Immunology and Physiology UrB RAS
Email: fake@neicon.ru
Junior scientific researcherof the laboratory of immunology of inflammation,
Ekaterinburg
Russian FederationO. I. Zabkov
Institute of Immunology and Physiology UrB RAS
Email: fake@neicon.ru
post-graduate student,
Ekaterinburg
Russian FederationV. A. Gritsenko
Institute of Cellular and Intracellular Symbiosis UrB RAS
Email: fake@neicon.ru
MD, Professor, head of the laboratory,
Orenburg
Russian FederationReferences
- Kaplan A., Lee M. W., Wolf A. J., Limon J. J., Becker C. A., Ding M., Murali R., Lee E. Y., Liu G. Y., Wong G. C. L., Underhill D.M. Direct Antimicrobial Activity of IFN-β. The Journal of Immunology, 2017, 198: 4036–4045.
- Meller S., Di Domizio J., Voo K. S., Friedrich H. C., Chamilos G, Ganguly D, Conrad C, Gregorio J, Le Roy D, Roger T, Ladbury J. E., Homey B, Watowich S, Modlin R. L., Kontoyiannis D. P., Liu Y. J. Arold S. T., Gilliet M. T(Н)17 cells promote microbial killing and innate immune sensing of DNA via interleukin 26.Nature immunology, 2015, V.16 № 9. – p. 970–979).
- Зурочка А. В., Зурочка В. А., Добрынина М. А., Зуева Е. Б., Дукардт В. В., Гриценко В. А., Тяпаева Я. В., Черешнев В. А. Феномен наличия уникальной комбинации иммунобиологических свойств у синтетического аналога активного центра гра ну ло цитар но-макрофагального колониестимулирующего фактора (ГМ-КСФ). Бюллетень Оренбургского научного центра УрО РАН. 2016. 2: 30c. [Электр. ресурс] (URL: http://elmag.uran.ru:9673/magazine/Numbers/2016-2/Articles/ZAV-2016-2.pdf).
- Справочник по микробиологическим и вирусологическим методам исследования /Под ред. М. О. Биргера. М.: Медицина, 1982. 464 с.
- Бухарин О. В., Гриценко В. А. Влияние in vitro препарата лейкоцитарного катионного белка “Интерцид” на Escherichia coli. Антибиот. и химиотер. 2000. 45 (1): 16–20.
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