Email this article THE ROLE OF NGAL FOR PREDICTING RENAL DAMAGE IN PEDIATRIC PRACTICE
- Authors: Kalmetyeva L.R.1, Ibrahimova L.G.1, Prolygina D.D.1
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Affiliations:
- Republican Сhildren Сlinical Нospital
- Issue: Vol 22, No 2-2 (2019)
- Pages: 789-791
- Section: ORIGINAL ARTICLES
- Submitted: 04.06.2020
- Accepted: 04.06.2020
- Published: 15.07.2019
- URL: https://rusimmun.ru/jour/article/view/302
- DOI: https://doi.org/10.31857/S102872210006697-1
- ID: 302
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Abstract
As it is known, serum creatinine and glomerular filtration rate are considered to be markers of kidney damage. In chronic kidney disease, these markers reveal a late stage of kidney damage, when drug therapy is not always effective and the process of kidney damage is irreversible. In recent years, special attention has been paid to the search for predictors of acute and relapses of chronic renal damage, which could lead to the detection of premorbid pathological changes in the kidneys, to determine the nature and differentiate the defeat of various parts of the nephron, to establish the stage of the process, to assess the severity of inflammation and the intensity of fi brogenesis. One of these early markers is NGAL are investigated.
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About the authors
L. R. Kalmetyeva
Republican Сhildren Сlinical Нospital
Author for correspondence.
Email: imun-lab@mail.ru
PhD, allergist-immunologist,
Ufa
Russian FederationL. G. Ibrahimova
Republican Сhildren Сlinical Нospital
Email: fake@neicon.ru
allergist-immunologist,
Ufa
Russian FederationD. D. Prolygina
Republican Сhildren Сlinical Нospital
Email: fake@neicon.ru
PhD, allergist-immunologist,
Ufa
Russian FederationReferences
- Kjeldsen L., Johnsen A.H., Sengeløv H., Borregaard N. Isolation and primary structure of NGAL, a novel protein associated with human neutrophil gelatinase // J. Biol. Chem. 1993; 268: 10425–10432. (Типовая, англоязычная).
- Mishra J., Ma Q., Prada A., Mitsnefes M., Zahedi K., Yang J., Barasch J., Devarajan P. Identification of neutrophil gelatinase-associated lipocalin as a novel early urinary biomarker for ischemic renal injury // Clin. J. Am. Soc. Nephrol. 2003; 14: 2534–2543. (Типовая, англоязычная).
- Jaya Mishra, Catherine Dent, Ridwan Tarabishi, Mark M Mitsnefes, Qing Ma, Caitlin Kelly, Stacey M Ruff , Kamyar Zahedi, Mingyuan Shao, Judy Bean, Kiyoshi Mori, Jonathan Barasch, Prasad Devarajan. Neutrophil gelatinase-associated lipocalin (NGAL) as biomarker for acute renal injury after cardiac surgery // Lancet. 2005; 365: 1231–1238. (Типовая, англоязычная). 4. Mishra J., Mori K., Devarajan P., Kelly C. Kidney NGAL is a novel early marker of acute injury following transplantation // Pediatr. Nephrol. 2006; 21: 856– 863. (Типовая, англоязычная).
- Wagener G., Jan M., Kim M., Mori K., Barasch J. M., Sladen R. N., Lee H. T. Association between increases in urinary neutrophil gelatinase-associated lipocalin and acute renal dysfunction after adult cardiac surgery // Anesthesiology. 2006; 105: 485–491. (Типовая, англоязычная).
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СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).