MICROBICIDAL EFFECT OF SECRETORY PRODUCTS OF NEUTROPHILS IN RELATION TO REPRESENTATIVES OF RESIDENT AND CONDITIONALY PATHOGENIC MICROFLORA OF A HUMAN BODY

Cover Page


Cite item

Full Text

Abstract

A study of 50 samples of intact and activated neutrophil supernatants from S. aureus (strain 209), E. сoli (strain M-17), Lactobacterium spp., Bifi dobacterium spp. has been conducted. It has been determined that in vitro induction of neutrophils by representatives of the resident and conditionally pathogenic microflora of the human body leads to secretion of biologically active products of different composition. Thus, the interaction of neutrophils with Lactobacterium spp. and, to a greater extent, Bifidobacterium spp. significantly increases the level of nitric oxide in supernatants, while the content of peroxidase and catalase does not change. This is accompanied by a significant increase in the microbicide of neutrophil secretion products in relation to S. aureus and E. coli, without affecting the viability of Lactobacterium spp. and Bifidobacterium spp.

About the authors

E. V. Kolbina

Federal State Budgetary Educational Institution of Higher Education «South-Ural State Medical University» of the Ministry of Healthcare of the Russian Federation

Author for correspondence.
Email: kaplech@mail.ru

PhD M.S., Senior Teacher of the Department of Microbiology, Virology, Immunology and Clinical Laboratory Diagnostics,

Chelyabinsk

Russian Federation

Yu. S. Shishkova

Federal State Budgetary Educational Institution of Higher Education «South-Ural State Medical University» of the Ministry of Healthcare of the Russian Federation

Email: fake@neicon.ru

MD M.S., Professor of the Department of Microbiology, Virology, Immunology and Clinical Laboratory Diagnostics,

Chelyabinsk

Russian Federation

E. A. Mezentseva

Federal State Budgetary Educational Institution of Higher Education «South-Ural State Medical University» of the Ministry of Healthcare of the Russian Federation

Email: fake@neicon.ru

PhD M.S., Docent of the Department of Microbiology, Virology, Immunology and Clinical Laboratory Diagnostics,

Chelyabinsk

Russian Federation

I. A. Kolbin

Federal State Budgetary Educational Institution of Higher Education «South-Ural State Medical University» of the Ministry of Healthcare of the Russian Federation

Email: fake@neicon.ru

Assistant of the Department of Microbiology, Virology, Immunology and Clinical Laboratory Diagnostics,

Chelyabinsk

Russian Federation

References

  1. Долгушин И. И., Андреева Ю. С., Мезенцева Е. А., Савочкина А. Ю., Плеханова Е. В., Свиридов М. А., Пешикова М. В. Нейтрофилы регулируют формирование микробиоценоза слизистых оболочек. Медицинская иммунология. 2006, 8; 2–3, 135– 136.
  2. Долгушин И. И., Андреева Ю. С., Савочкина А. Ю. Нейтрофильные внеклеточные ловушки и методы оценки функционального статуса нейтрофилов. Издательство РАМН, Москва 2009, 208.
  3. Плеханова Е. В. Влияние факторов цервикального секрета (факультативной и резидентной флоры, муцина) на функциональные свойства нейтрофилов: дис. … канд. мед. наук. Челябинск, 2007.

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c) 2019 Kolbina E.V., Shishkova Y.S., Mezentseva E.A., Kolbin I.A.

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: серия ПИ № 77 - 11525 от 04.01.2002.


This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies