THE MODEL OF PSORIASIFORM DERMATITIS IN MICE INDUCED BY INTRADERMAL ADMINISTRATION OF RECOMBINANT HUMAN IL-36γ

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Abstract

We developed and characterized the model of psoriasiform dermatitis in mice induced by induced by intradermal administration of recombinant human IL-36γ. Induced skin lesions resemble human psoriasis in means of both macroscopic (PASI) and microscopic features (acanthosis, parakeratosis, dermal leucocyte infiltration). This model can be used for anti-psoriatic drugs efficiency research.

About the authors

A. A. Kolobov

State Research Institute of Highly Pure Biopreparations

Author for correspondence.
Email: al.a.kolobov@hpb.spb.ru

PhD, Junior Scientist of Laboratory of Immunopharmacology,

Saint-Petersburg

Russian Federation

T. A. Sazonova

State Research Institute of Highly Pure Biopreparations

Email: fake@neicon.ru

Junior Biologist of Department of Preclinical Studies,

Saint-Petersburg

Russian Federation

G. V. Alexandrov

State Research Institute of Highly Pure Biopreparations

Email: fake@neicon.ru

PhD, Deputy Head of Department of Preclinical Studies,

Saint-Petersburg

Russian Federation

A. V. Petrov

State Research Institute of Highly Pure Biopreparations

Email: fake@neicon.ru

PhD, Head of Laboratory of Immunopharmacology, 

Saint-Petersburg

Russian Federation

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Copyright (c) 2019 Kolobov A.A., Sazonova T.A., Alexandrov G.V., Petrov A.V.

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This work is licensed under a Creative Commons Attribution 4.0 International License.
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