Email this article USE OF STATINS FOR THE TREATMENT OF NON-INFECTIOUS UVEITIS
- Authors: Biryukova A.A.1, Shirinsky I.V.2
-
Affiliations:
- S. N. Fyodorov Eye Microsurgery Complex, Novosibirsk Branch
- Federal State Budgetary Scientifi c Institution Research Institute of Fundamental and Clinical Immunology
- Issue: Vol 22, No 2-1 (2019)
- Pages: 165-167
- Section: ORIGINAL ARTICLES
- Submitted: 11.04.2020
- Accepted: 11.04.2020
- Published: 15.04.2019
- URL: https://rusimmun.ru/jour/article/view/32
- DOI: https://doi.org/10.31857/S102872210006437-5
- ID: 32
Cite item
Full Text
Abstract
Inhibitors of inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase or statins, are used for the treatment of cardiovascular diseases and dyslipidemia. Immunomodulating and anti-infl ammatory properties of statins provide a rationale for their use in various autoimmune diseases including noninfectious uveitis. In this article we present literature data on the use of statins in the experimental models of non-infectious uveitis and on the epidemiological studies showing prophylactic eff ect of statins against uveitis. In our pilot, open-label, randomized study we demonstrated effi cacy and safety of treatment of uveitis with simvastatin in addition to conventional treatment. In conclusion, current data provide a rationale for a randomized, placebo controlled study of statins in uveitis.
About the authors
A. A. Biryukova
S. N. Fyodorov Eye Microsurgery Complex, Novosibirsk Branch
Author for correspondence.
Email: fake@neicon.ru
PhD student, ophthalmologist,
Novosibirsk
Russian FederationI. V. Shirinsky
Federal State Budgetary Scientifi c Institution Research Institute of Fundamental and Clinical Immunology
Email: ivan.shirinsky@gmail.com
leading research scientist, MD, PhD, Laboratory of Clinical Immunopharmacology,
Novosibirsk
Russian FederationReferences
- Durrani K., Zakka F. R., Ahmed M., Memon M., Siddique S. S., Foster C. S. Systemic therapy with conventional and novel immunomodulatory agents for ocular infl ammatory disease. Surv Ophthalmol 2011, 56(6):474–510.
- Harry R., Gegg M., Hankey D., Zambarakji H., Pryce G., Baker D., Calder V., Adamson P., Greenwood J. Suppression of autoimmune retinal disease by lovastatin does not require Th2 cytokine induction. J Immunol 2005, 174(4):2327–2335.
- Kohno H., Sakai T., Saito S., Okano K., Kitahara K. Treatment of experimental autoimmune uveoretinitis with atorvastatin and lovastatin. Exp Eye Res 2007, 84(3):569–576.
- Borkar D. S., Tham V. M., Shen E., Parker J. V., Uchida A., Vinoya A. C., Acharya N. R. Association between statin use and uveitis: results from the Pacifi c Ocular Infl ammation study. Am J Ophthalmol 2015, 159(4):707–713.
- Shirinsky I. V., Biryukova A. A., Shirinsky V. S. Simvastatin as an Adjunct to Conventional Therapy of Noninfectious Uveitis: A Randomized, Open-Label Pilot Study. Curr Eye Res 2017, 42(12):1713–1718.
Supplementary files
СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).