INFLUENCE OF GLUTAMYL-TRYPTOPHAN ON CYTOKINE SECRETION, WOUND HEALING, AND ANTIOXIDANT SYSTEM IN VITRO AND IN VIVO

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Abstract

Dipeptide glutamyl-tryptophan influences on metabolic processes in different cells, stimulates the functional activity of immune cells, restores disorders in the antioxidant system, improves tissue regeneration, accelerates wound healing, activates the functions of connective tissue cells, endotheliocytes, macrophages and leukocytes in the outbreak damage.

About the authors

T. A. Kudriavtceva

ZAO MPSPS CYTOMED

Author for correspondence.
Email: tkudriavtceva@cytomed.ru

PhD, Chief Scientific Officer Department of Science,

St Petersburg

Russian Federation

E. A. Starikova

Institute of Experimental Medicine

PhD Leading Reseacher Department of Immunology,

St Petersburg

Russian Federation

I. V. Voronkina

Institute of Cytology of the Russian Academy of Sciences (RAS)

PhD Leading Reseacher Department of Cell Cultures,

St Petersburg

Russian Federation

V. S. Smirnov

ZAO MPSPS CYTOMED

MD, Professor, Heard of Department of Science,

St Petersburg

Russian Federation

References

  1. Смирнов В. С., Петленко С. В. Комплексный препарат «Цитовир-3». В кн.: Грипп и острые респираторные вирусные инфекции (характериcтика, патогенез, профилактика и лечение), изд. 3-е перераб. и доп. – СПб: Гиппократ 2019. 128–163.
  2. Shevtsov M. A., Smagina L. V., Kudriavtceva T. A., Vo ronkina I. V. Glu-Trp-ONa or its acylated analogue (R-GluTrp-ONa) administration enhances the wound healing in the model of chronic skin wounds in rabbits. Drug Design, Development and Therapy 2015:9, 1717–1727.

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Copyright (c) 2019 Kudriavtceva T.A., Starikova E.A., Voronkina I.V., Smirnov V.S.

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