COMPARATIVE CHARACTERISTICS OF THE SUBPOPULATION COMPOSITION OF LYMPHOCYTES AND HEAT SHOCK PROTEIN IN PATIENTS WITH VIBRATION DISEASE

Cover Page


Cite item

Full Text

Abstract

Comparative analysis of the subpopulations of lymphocytes in patients with vibration disease (VB) from the effects of local vibration revealed the features of the immune response, characterized by increasing the absolute amount of CD3+-, CD4+-, CD8+- lymphocytes and decreased the percentage of CD20+-, CD25+-lymphocytes. In patients with VB from the effects of combined vibration, an increase in the absolute number of CD3+-, CD4+ -, CD8+ -, CD16+ -, CD20+-, CD25+-, CD95+-lymphocytes was observed, which indicates the activation of lymphocyte apoptosis under conditions of pronounced stimulation of the immune system. A decrease in the level of HSP70 in the serum of patients with VB from exposure to local vibration indicates its accumulation inside the cell and the protection of the processes of biosynthesis and the structural integrity of proteins in the damaged cell due to B-lymphocytes. 

About the authors

S. I. Kurchevenko

FSBI “East-Siberian Institute of Medical and Ecological Research”

Author for correspondence.
Email: immun11@yandex.ru

PhD, Researcher of the laboratories of Immune and biochemical and molecular and genetic research,

Angarsk

Russian Federation

G. M. Bodienkova

FSBI “East-Siberian Institute of Medical and Ecological Research”;
Irkutsk National Research Technical University

Email: fake@neicon.ru

DMS, Professor, Head of the Laboratories of Immune and biochemical and molecular and genetic research, Angarsk;

Professor, Department of Industrial Ecology and Safety of Vital Functions, Irkutsk

Russian Federation

O. L. Lakhman

FSBI “East-Siberian Institute of Medical and Ecological Research”

Email: fake@neicon.ru

Professor of the Russian Academy of Sciences, DMS, Professor, Director,

Angarsk

Russian Federation

References

  1. Бабанов С. А., Татаровская Н. А. Вибрационная болезнь: современное понимание и дифференциальный диагноз. Русский медицинский журнал. Медицинское обозрение. 2013, 21; 35, 1777–1784.
  2. Bodienkova G. M., Kurchevenko S. The relationship between the cytokine concentrations and levels of antibodies to neuronal proteins in workers who were exposed to vibration. Neurochemical Journal. 2016, 33; 1, 85–89.
  3. Потапнев М. П. Аутофагия, апоптоз, некроз, клеток и иммунное распознавание своего и чужого. Иммунология. 2014, 35; 2, 95–102.
  4. Yasuyuki A., Takayoshi J. and Tomohiko O. Oral Treponemes and their outer membrane extracts activate human gingival epithelial cells through toll like receptor 2. Infection and Immunity. 2003, 71; 2, 717–725.

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c) 2019 Kurchevenko S.I., Bodienkova G.M., Lakhman O.L.

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: серия ПИ № 77 - 11525 от 04.01.2002.