Email this article SYNERGISTIC INTERACTIONS OF NOD1 AND TLR4 RECEPTORS OF INNATE IMMUNITY
- Authors: Murugina N.E.1, Budikhina A.S.1, Maximchik P.V.2, Dagil Y.A.1, Balyasova L.S.1, Murugin V.V.1, Chkadua G.Z.3, Pinegin B.V.1, Pashenkov M.V.1
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Affiliations:
- National Research Center “Institute of Immunology” of the Federal Medical-Biological Agency of Russia
- Lomonosov Moscow State University
- FSBI “N. N. Blokhin National Medical Research Center of Oncology” of the Ministry of Health of the Russian Federation
- Issue: Vol 22, No 2-2 (2019)
- Pages: 858-860
- Section: ORIGINAL ARTICLES
- URL: https://rusimmun.ru/jour/article/view/364
- DOI: https://doi.org/10.31857/S102872210006649-8
- ID: 364
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About the authors
N. E. Murugina
National Research Center “Institute of Immunology” of the Federal Medical-Biological Agency of Russia
Author for correspondence.
Email: fake@neicon.ru
junior researcher, Laboratory of Clinical Immunology,
Moscow
Russian FederationA. S. Budikhina
National Research Center “Institute of Immunology” of the Federal Medical-Biological Agency of Russia
Email: fake@neicon.ru
PhD, researcher, Laboratory of Clinical Immunology,
Moscow
Russian FederationP. V. Maximchik
Lomonosov Moscow State University
Email: fake@neicon.ru
PhD, researcher, Faculty of Fundamental Medicine,
Moscow
Russian FederationY. A. Dagil
National Research Center “Institute of Immunology” of the Federal Medical-Biological Agency of Russia
Email: fake@neicon.ru
researcher, Laboratory of Clinical Immunology,
Moscow
Russian FederationL. S. Balyasova
National Research Center “Institute of Immunology” of the Federal Medical-Biological Agency of Russia
Email: fake@neicon.ru
junior researcher, Laboratory of Clinical Immunology,
Moscow
Russian FederationV. V. Murugin
National Research Center “Institute of Immunology” of the Federal Medical-Biological Agency of Russia
Email: fake@neicon.ru
PhD, researcher, Laboratory of Clinical Immunology,
Moscow
Russian FederationG. Z. Chkadua
FSBI “N. N. Blokhin National Medical Research Center of Oncology” of the Ministry of Health of the Russian Federation
Email: fake@neicon.ru
PhD, senior researcher, Laboratory of experimental diagnostics and biotherapy of tumors,
Moscow
Russian FederationB. V. Pinegin
National Research Center “Institute of Immunology” of the Federal Medical-Biological Agency of Russia
Email: fake@neicon.ru
Professor, Doctor of medical sciences, Head of the Department of immunodiagnostics and immunocorrection,
Moscow
Russian FederationM. V. Pashenkov
National Research Center “Institute of Immunology” of the Federal Medical-Biological Agency of Russia
Email: mvpashenkov@yandex.ru
Doctor of medical sciences, Acting head of the Laboratory of Clinical Immunology,
Moscow
Russian FederationReferences
- Tukhvatulin A. I., Gitlin I. I., Shcheblyakov D. V., Artemicheva N. M., Burdelya L. G., Shmarov M.M, Naroditsky B. S., Gudkov A. V., Gintsburg A. L., Logunov D. Y. Combined stimulation of Toll-like receptor 5 and NOD1 strongly potentiates activity of NF-kappaB, resulting in enhanced innate immune reactions and resistance to Salmonella enterica serovar Typhimurium infection. Infect Immun. 2013, 81 (10), 3855–64.
- Van Heel D. A., Ghosh S., Butler M., Hunt K., Foxwell B. M.G., Mengin-Lecreulx D., Playford R. J. Synergistic enhancement of Toll-like receptor responses by NOD1 activation. Eur J Immunol. 2005, 35, 2471– 2476
- Fritz J. H., Girardin S. E., Fitting C., Werts C., MenginLecreulx D., Caroff M., Cavaillon J-M., Philpott D. J. and Adib-Conquy M. Synergistic stimulation of human monocytes and dendritic cells by Toll-like receptor 4 and NOD1- and NOD2-activating agonists. Eur J Immunol. 2005, 35 (8), 2459–70.
- O’Neill L. A., Pearce E. J. Immunometabolism governs dendritic cell and macrophage function. J Exp Med 2015, 213, 15–23.
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