Email this article INFLUENCY OF INFLUENCES OF REGULATORY PEPTIDES AND RECOMBINANT IFNα ON THE PHENOTYPE OF THE SUBSET CD66b+CD33+CD16+CD11b+NEUTROFIL GRANULOCYTES IN VITRO
- Authors: Nesterova I.V.1,2, Chudilova G.A.1, Kovaleva S.V.1, Lomtatidze L.V.1, Rusinova T.V.1, Tarakanov V.A.1, Barova N.K.1, Pavlenko V.N.1
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Affiliations:
- Kuban State Medical University
- Peoples’ Friendship University of Russia
- Issue: Vol 22, No 2-2 (2019)
- Pages: 867-869
- Section: ORIGINAL ARTICLES
- Submitted: 21.06.2020
- Accepted: 21.06.2020
- Published: 15.07.2019
- URL: https://rusimmun.ru/jour/article/view/367
- DOI: https://doi.org/10.31857/S102872210006645-4
- ID: 367
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Abstract
A model of the bacterial process under the influence of fMLP was reproduced in the in vitro system, which made it possible to reveal the features of the transformation of CD66b+CD33+CD16+CD11b+neutrofi l granulocytes (NG). Multidirectional effects of mono-effects of peptides and rIFNα2b on the expression of the studied markers of NG in healthy children were identified. The modulating effect of rIFNα2b on the transformed fMLP phenotype of NG is associated with polarization into an anti-inflammatory phenotype.
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About the authors
I. V. Nesterova
Kuban State Medical University;Peoples’ Friendship University of Russia
Author for correspondence.
Email: inesterova1@yandex.ru
Chief Researcher, Central Research Laboratory;
MD, Professor, Department of Allergology and Immunology,
Russian Federation
G. A. Chudilova
Kuban State Medical University
Email: fake@neicon.ru
PhD (Biological Sciences), Head of Department, Central Research Laboratory,
Krasnodar
Russian FederationS. V. Kovaleva
Kuban State Medical University
Email: fake@neicon.ru
Ph.D. (Medical Science), Senior Researcher, Central Research Laboratory,
Krasnodar
Russian FederationL. V. Lomtatidze
Kuban State Medical University
Email: fake@neicon.ru
PhD (Biological Sciences), Senior Researcher, Central Research Laboratory,
Krasnodar
Russian FederationT. V. Rusinova
Kuban State Medical University
Email: fake@neicon.ru
Ph.D. (Biological Sciences), Researcher, Central Research Laboratory,
Krasnodar
Russian FederationV. A. Tarakanov
Kuban State Medical University
Email: fake@neicon.ru
MD, Professor, Head of the Department of Surgical Diseases of Childhood,
Krasnodar
Russian FederationN. K. Barova
Kuban State Medical University
Email: fake@neicon.ru
PhD, Assistant of the Department of Surgical Diseases of Childhood,
Krasnodar
Russian FederationV. N. Pavlenko
Kuban State Medical University
Email: fake@neicon.ru
resident, Department of Clinical Immunology, Allergology and Laboratory Diagnostics,
Krasnodar
Russian FederationReferences
- Нестерова И. В., Колесникова Н. В., Чудилова Г. А., Ломтатидзе Л. В., Ковалева С. В., Евглевский А. А., Нгуен Т. З.Л. Новый взгляд на нейтрофильные гранулоциты: переосмысление старых догм. (Часть 2). Инфекция и иммунитет 2018, 8(1), 7–18.
- Scapini P., Marini O., Tecchio C., Cassatella M. A. Human neutrophils in the saga of cellular heterogeneity: insights and open questions. Immunol. Rev. 2016, 273(1) 48–60.
- Garley M., Jabłońska E. Heterogeneity among neutrophils. Arch. Immunol. Ther. Exp. (Warsz). 2018, 66(1), 21–30.
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