POPULATION COMPOSITION OF NEUTROPHILS IN THE TUBERCULOUS PROCESS

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Abstract

Neutrophils are the first line of defense against infectious diseases. The contribution of neutrophils to the pathogenesis of tuberculosis is controversial and not fully understood. In this study, we analyzed the heterogeneity of neutrophil populations in patients with tuberculosis and control subjects. In patients with tuberculosis, there is an increase in the number of low-density neutrophils compared with control subjects. We have found that the low-density neutrophil population is heterogeneous and contains a subpopulation of activated cells.

About the authors

Y. V. Serdyuk

Сentral tuberculosis research institute

Email: yv_serdyk@mail.ru

PhD student, Junior Staff Researcher Laboratory of biotechnology,

Chelyabinsk

Russian Federation

T. A. Nenasheva

Сentral tuberculosis research institute

Email: fake@neicon.ru

PhD, Senior Staff Researcher Laboratory of biotechnology,

Chelyabinsk

Russian Federation

I. Yu. Nikitina

Сentral tuberculosis research institute

Email: fake@neicon.ru

PhD, Senior Staff Researcher Laboratory of biotechnology,

Chelyabinsk

Russian Federation

N. L. Karpina

Сentral tuberculosis research institute

Email: fake@neicon.ru

Doctor of Medical Sc., Head of the Consultative department,

Chelyabinsk

Russian Federation

I. V. Lyadova

Сentral tuberculosis research institute

Author for correspondence.
Email: fake@neicon.ru

Doctor of Medical Sc., Head of the Laboratory of biotechnology,

Chelyabinsk

Russian Federation

References

  1. Almeida F. M., Ventura T. L., Amaral E. P., Ribeiro S. C., Calixto S.D., Manhães M. R., Rezende A. L., Souzal G. S., et al. (2017).“Hypervirulent Mycobacterium tuberculosis strain triggers necrotic lung pathology associated with enhanced recruitment of neutrophils in resistant C57BL/6 mice”. PloS one, 12(3): e0173715
  2. Singhal S., Bhojnagarwala P. S., O’Brien S., Moon E. K., Garfall A. L., Rao A. S., Quatromoni J. G., Stephen T. L., Litzky L., Deshpande C., et al. (2016). “Origin and role of a subset of tumor-associated neutrophils with antigen-presenting cell features in early-stage human lung cancer”.Cancer Cell, 30(1):120–135
  3. Tsiganov E. N., Verbina E. M., Radaeva T. V., Sosunov V. V., Kosmiadi G. A., Nikitina I. Y. and Lyadova I. V., (2014). “Gr-1dimCD11b+ immature myeloidderived suppressor cells but not neutrophils are markers of lethal tuberculosis infection in mice”. TheJournal of Immunology, 192(10:4718–4727.
  4. Lyadova I. V., (2017). “Neutrophils in Tuberculosis: Heterogeneity Shapes the Way?” Mediators of Inflammation, 2017:8619307
  5. Deng Y., Ye J., Luo Q., Huang Z., Peng Y., Xiong G., et al. (2016). “Low-density granulocytes are elevated in mycobacterial infection and associated with the severity of tuberculosis”. PloS one, 11(4): e0153567.

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Copyright (c) 2019 Serdyuk Y.V., Nenasheva T.A., Nikitina I.Y., Karpina N.L., Lyadova I.V.

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