Email this article THE ROLE OF B1 AND B2 LYMPHOCYTES IN THE FORMATION OF DIFFERENT VARIANTS OF RHEUMATOID ARTHRITIS
- Authors: Sizyakina L.P.1, Kharitonova M.V.1
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Affiliations:
- Rostov State Medical University
- Issue: Vol 22, No 2-2 (2019)
- Pages: 918-920
- Section: ORIGINAL ARTICLES
- Submitted: 24.07.2020
- Accepted: 24.07.2020
- Published: 15.07.2019
- URL: https://rusimmun.ru/jour/article/view/405
- DOI: https://doi.org/10.31857/S102872210006542-1
- ID: 405
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Abstract
The results of the phenotypic characteristics of B1 and B2 lymphocytes of patients with seropositive (51 people) and seronegative (41 people) variants of the course of articular form of rheumatoid arthritis are presented. An increase in the content of B1 lymphocytes in both seronegative and seropositive variants was shown. A distinctive feature of B2 lymphocytes in the seropositive compared with the seronegative option is to enhance the activation processes and decrease the intensity of apoptosis with the progression of the autoimmune process.
About the authors
L. P. Sizyakina
Rostov State Medical University
Author for correspondence.
Email: msiziakina@mail.ru
MD, PhD, Head of the Department of Clinical Immunology and Allergology, Director of the Institute of Clinical Immunology,
Rostov-on-Don
Russian FederationM. V. Kharitonova
Rostov State Medical University
Email: fake@neicon.ru
Post-Graduate Student of the Department of Clinical Immunology and Allergology,
Rostov-on-Don
Russian FederationReferences
- Насонов Е. Л., Александрова Е. Н., Новиков А. А. Аутоиммунные ревматические заболевания ‒ проблемы иммунопатологии и персонифицированной терапии // Вестн. РАМН. – 2015. – Т. 70, № 2. – С. 169–182.
- Bugatti S. B cell autoimmunity and bone damage in rheumatoid arthritis / S. Bugatti, L. Bogliolo, C. Montecucco, A. Manzo // Reumatismo. – 2016. – Vol. 68, N3. – P. 117–125.
- Сизякина Л. П., Харитонова М. В. Характеристика В2-лимфоцитов у пациентов с серонегативным ревматоидным артритом суставной формы // Иммунология. – 2018. – Т. 39, № 2–3. – С. 134–137.
Supplementary files
СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).