INFLUENCE OF DIFFERENT INTERFERON-GAMMA (IFN-γ) CONCENTRATIONS ON CELLS OF THE IMMUNE SYSTEM IN VITRO

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Abstract

The work was aimed at determining the possibility of activation of lymphocytes and natural killer cells with the addition of various concentrations of IFN-γ in vitro. The results showed that IFN- γ promotes maturation of T eff ector cell-mediated immunity system.

About the authors

A. O. Sitkovskaya

Rostov Research Institute of Oncology

Author for correspondence.
Email: grankina.anastasia@mail.ru

Head of the Cell Technology Laboratory,

Rostov-on-Don

Russian Federation

A. B. Sagakyants

Rostov Research Institute of Oncology

Email: fake@neicon.ru

Ph.D., Head of the Laboratory of tumor immunophenotyping,

Rostov-on-Don

Russian Federation

S. Yu. Filippova

Rostov Research Institute of Oncology

Email: fake@neicon.ru

Researcher, Laboratory of Cell Technologies of the laboratory of tumor immunophenotyping,

Rostov-on-Don

Russian Federation

I. V. Mezhevova

Rostov Research Institute of Oncology

Email: fake@neicon.ru

Junior researcher of the Laboratory of tumor immunophenotyping,

Rostov-on-Don

Russian Federation

E. S. Bondarenko

Rostov Research Institute of Oncology

Email: fake@neicon.ru

Junior researcher of the Laboratory of tumor immunophenotyping,

Rostov-on-Don

Russian Federation

K. G. Statsenko

Rostov Research Institute of Oncology

Email: fake@neicon.ru

student,

Rostov-on-Don

Russian Federation

M. M. Popova

Rostov Research Institute of Oncology

Email: fake@neicon.ru

student,

Rostov-on-Don

Russian Federation

References

  1. Gama H. P., Rocha A. J., Silva C. J., Mendes M. F., Veiga I. C., Lancelotti C. I., Andrande V. P., Tibery C. P. Meningioma growth during interferon beta-1A treatment for multiple sclerosis. Arq Neuropsiquiatr. 2008, 66(2B), 402–404.
  2. Мухачева М. В., Бейн Б. Н. Роль интерферонов в противоопухолевом иммунитете у больных с церебральными опухолями. Фундаментальные исследования. 2015, 1(7), 1486–1490.
  3. Златник Е. Ю., Ситковская А. О., Непомнящая Е. М., Джандигова Ф. Р., Ващенко Л. Н. Достижения и перспективы клеточных технологий на основе активированных лимфоцитов в лечении злокачественных опухолей. Казанский медицинский журнал. 2018, 5, 792–801.

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Copyright (c) 2019 Sitkovskaya A.O., Sagakyants A.B., Filippova S.Y., Mezhevova I.V., Bondarenko E.S., Statsenko K.G., Popova M.M.

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This work is licensed under a Creative Commons Attribution 4.0 International License.
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