MANIFESTATION OF REGENERATORY POTENCIAL OF EXTRA-ISLET INSULIN-PRODUCING PANCREATIC CELLS AT THE EXPERIMENTAL DIABETES TYPE2 AND AT ADMINISTRATION OF 3-AMINOPHTALHYDRASIDE

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Abstract

Restoration of quantity, size of cells and their functional activity reflect the possibility of tissue to regenerate. 3-aminophtalhydrazide (APH), which effects to the macrophage activation: classic vs. alternative, (М1→М2), increases quantity and sizes of insulin-producing cells, localized in pancreatic ducts. Besides, APH leads to increase of optical density of insulin both in beta-cells and insulin-producing cells, located in acinar part of the pancreas and in ducts.

About the authors

K. V. Sokolova

FederalState Budget Institution of Science «Institute of Immunology and Physiology» Ural Branch Russian Academy of Science;
Federal State Autonomous Educational Institution of Higher Education «Ural Federal University named after the fi rst President of Russia B. N. Yeltsin»

Author for correspondence.
Email: kssokolova@bk.ru

jun.res., Laboratory of morphology and biochemistry;

PhD student, Department of medical biochemistry and biophysics,

Yekaterinburg

Russian Federation

I. F. Gette

FederalState Budget Institution of Science «Institute of Immunology and Physiology» Ural Branch Russian Academy of Science;
Federal State Autonomous Educational Institution of Higher Education «Ural Federal University named after the first President of Russia B. N. Yeltsin»

Email: fake@neicon.ru

PhD, sen.res., Laboratory of morphology and biochemistry;

sen.res., Department of Immunochemistry,

Yekaterinburg

Russian Federation

V. V. Emelyanov

Federal State Autonomous Educational Institution of Higher Education «Ural Federal University named after the first President of Russia B. N. Yeltsin»

Email: fake@neicon.ru

PhD, assistant professor, Department of Immunochemistry, Department of Medical Biochemistry and biophysics,

Yekaterinburg

Russian Federation

M. T. Abidov

Institute of Immunopathology

Email: fake@neicon.ru

DM, Institute of Immunopathology,

Ljublijana

Slovenia

References

  1. Xia B., Zhan X. R., Yi R., Yang B. Can pancreatic ductderived progenitors be a source of islet regeneration? Biochem.Biophys. Res.Commun. 2009, Jun 12; 383(4): 383–5.
  2. Иванова В. Ф., Пузырев А. А. Структурно-функци о нальные изменения в поджелудочной железе белой крысы при введении глюкозы. // Морфология, 2006, том 129, № 1, 67–71.
  3. Clayton H. W., Osipovich A. B., Stancill J. S., Schneider J. D., Vianna P. G., Shanks C. M., Yuan W., Gu G., Manduchi E., Stoeckert C. J., Jr., Magnuson M. A. Pancreatic Inflammation Redirects Acinar to Beta Cell Reprogramming. Cell Rep., 2016, Nov 15, 17(8): 2028–2041.
  4. Спасов А. А., Воронкова М. П., Снигур Г. Л., Чепляева Н. И., Чепурнова М. В. Экспериментальная модель сахарного диабета типа 2. Биомедицина, 2011, № 3, с. 12–18.
  5. Danilova I. G., Bulavintceva T. S., Gette I. F., Medvedeva S. Y., Emelyanov V. V., Abidov M. T. Partial recovery from alloxan-induced diabetes by sodium phthalhydrazide in rats. Biomedicine and Pharmacotherapy, 2017, 95, 103–110.

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Copyright (c) 2019 Sokolova K.V., Gette I.F., Emelyanov V.V., Abidov M.T.

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