THE STUDY OF ABILITY OF DENDRITIC CELLS LOADED WITH AUTOLOGICAL TUMOR LIZATE OF PATIENT SWITHHIGH-GRADE GLIOMA TO ACTIVATE ANTIGEN-SPECIFIC T-CELL RESPONSE IN VITRO

Cover Page

Cite item

Abstract

In the present work we demonstrated that IFNα-induced dendritic cells (IFN-DCs) loaded with a lysate of autologous tumor cells of high-grade glioma patients (DCLYS) more eff ectively stimulated the proliferative response of autologous T-cells compared with unloaded IFN-DCs (DCLPS) and did not induce apoptosis of CD4+ and CD8+ T cells. Moreover, DCLYS activated cytotoxic CD8+ T cells (in the degranulation test) in cultures of autologous mononuclear cells of studied patients. 

About the authors

E. D. Soloveva

Novosibirsk state university

Author for correspondence.
Email: fake@neicon.ru

6th year student of the Institute of Medicine and Psychology V. Zelman,

Novosibirsk

Russian Federation

T. V. Tyrinova

Institute of Fundamental and Clinical Immunology

Email: ct_lab@mail.ru

PhD, researcher, laboratory of cellular immunotherapy,

Novosibirsk

Russian Federation

A. V. Kalinovsky

Federal Neurosurgical Center, Ministry of Health of the Russian Federation

Email: fake@neicon.ru

PhD, head of surgical unit, 

Novosibirsk

Russian Federation

S. V. Mishinov

«Novosibirsk Research Institute of Traumatology and Orthopedics them. Y. L. Tsivyana», Ministry of Health of the Russian Federation

Email: fake@neicon.ru

PhD, neurosurgeon, neurosurgery department,

Novosibirsk

Russian Federation

S. V. Chernov

Federal Neurosurgical Center, Ministry of Health of the Russian Federation

Email: fake@neicon.ru

PhD, head of neurooncology department,

Novosibirsk

Russian Federation

V. V. Stupak

«Novosibirsk Research Institute of Traumatology and Orthopedics them. Y. L. Tsivyana», Ministry of Health of the Russian Federation

Email: fake@neicon.ru

MD, professor, head of neurosurgery department,

Novosibirsk

Russian Federation

References

  1. Назаркина Ж. К., Лактионов П. П. Получение дендритных клеток для иммунотерапии раковых заболеваний. Биомедицинская химия, Новосибирск 2015, 30–40.

Copyright (c) 2019 Soloveva E.D., Tyrinova T.V., Kalinovsky A.V., Mishinov S.V., Chernov S.V., Stupak V.V.

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Свидетельство о регистрации СМИ ПИ № 77 - 11525 от 04.01.2002 выдано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).


This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies