LYMPHOCYTE SUBPOPULATION PROFILE IN PATIENTS WITH METABOLIC SYNDROME AND IT’S CHANGE UNDER THE INFLUENCE OF ADIPOKINS IN EXPERIMENTAL CONDITIONS

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Abstract

An important role in the regulation of immune interactions in metabolic syndrome (MS) belongs to leptin and adiponectin, their levels in peripheral blood are well known, while the specific effects of these mediators on human lymphocytes are not well understood. In this work, we evaluated the subpopulations of lymphocytes in patients with metabolic syndrome in vivo, and studied the expression of activation markers of peripheral blood lymphocytes after incubation with leptin and adiponectin at concentrations close to those of metabolic syndrome.

About the authors

V. A. Sumerkina

Federal State Budgetary Educational Institution of Higher Education «South-Urals State Medical University» of the Ministry of Healthcare of Russian Federation

Author for correspondence.
Email: veronika.sumerkina@mail.ru

PhD, Leading Researcher of the Central Research Laboratory,

Chelyabinsk

Russian Federation

L. F. Telesheva

Federal State Budgetary Educational Institution of Higher Education «South-Urals State Medical University» of the Ministry of Healthcare of Russian Federation

Email: fake@neicon.ru

Ph D., professor of Department of Microbiology, Virology, Immunology and Clinical Laboratory Diagnostics,

Chelyabinsk

Russian Federation

E. S. Golovneva

Federal State Budgetary Educational Institution of Higher Education «South-Urals State Medical University» of the Ministry of Healthcare of Russian Federation

Email: fake@neicon.ru

Ph D., professor of Department of Normal Physiology named after academician Yu. M. Zakharov,

Chelyabinsk

Russian Federation

I. L. Baturina

Federal State Budgetary Educational Institution of Higher Education «South-Urals State Medical University» of the Ministry of Healthcare of Russian Federation

Email: fake@neicon.ru

PhD, Senior Researcher of Immunology Research Institute,

Chelyabinsk

Russian Federation

Yu. V. Naimushina

Federal State Budgetary Educational Institution of Higher Education «South-Urals State Medical University» of the Ministry of Healthcare of Russian Federation

Email: fake@neicon.ru

PhD, Associate Professor of Department of Faculty Surgery,

Chelyabinsk

Russian Federation

References

  1. Fujita Y., Murakami M., Ogawa M. Y., Masuzaki H., Tanaka M., Ozaki S., Nakao K., Mimori T. Leptin inhibits stress-induced apoptosis of T lymphocytes. ClinExpImmunol. 2002, 128 (1), 21–26.
  2. Sánchez-Margalet V., Martín-Romero C., González-Yanes C., Goberna R., Najib S., Gonzalez-Yanes C. Leptin receptor (Ob-R) expression is induced in peripheral blood mononuclear cells by in vitro activation and in vivo in HIV-infected patients. ClinExpImmunol. 2002, 129 (1), 119–124.
  3. Орлова Е. Г., Ширшев С. В. Роль лептина в контроле экспрессии активационных мембранных молекул разными субпопуляциями Т-лимфоцитов. Известия Российской академии наук. Серия биологическая. 2009, 4, 401–405.

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Copyright (c) 2019 Sumerkina V.A., Telesheva L.F., Golovneva E.S., Baturina I.L., Naimushina Y.V.

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