Email this article EXPRESSION OF VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTORS 1 (VEGFR-1) AND THEIR ROLE IN THE REGULATION OF T CELL PROLIFERATION
- Authors: Tashkina E.A.1, Leplina O.Y.1, Batorov E.V.1, Ostanin A.A.1, Pasman N.M.2
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Affiliations:
- Federal Budget Institution of Science «Research Institute of Fundamental and Clinical Immunology»
- Novosibirsk National Research State University
- Issue: Vol 22, No 2-2 (2019)
- Pages: 942-944
- Section: ORIGINAL ARTICLES
- Submitted: 24.07.2020
- Accepted: 24.07.2020
- Published: 15.07.2019
- URL: https://rusimmun.ru/jour/article/view/413
- DOI: https://doi.org/10.31857/S102872210006534-2
- ID: 413
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Abstract
The expression of vascular endothelial growth factor receptors-1 (VEGFR-1) on CD4+ and CD8+ donor T lymphocytes in mononuclear cell (MNC) cultures, as well as the eff ect of placental growth factor (PlGF) on T cell proliferation have been investigated. Freshly isolated T cells had low expression of VEGFR-1, which increased during spontaneous cultivation of T cells and most strongly upon activation of T lymphocytes with aCD3 antibodies. The maximum increase in VEGFR-1 – positive CD4+ and CD8+ T cells is observed at 48 hours. PlGF in a wide dose range inhibits the proliferation of aCD3- stimulated T cells, suppressing CD4+ and CD8+ T lymphocyte division to the same extent.
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About the authors
E. A. Tashkina
Federal Budget Institution of Science «Research Institute of Fundamental and Clinical Immunology»
Author for correspondence.
Email: ct_lab@mail.ru
Postgraduate Student, Laboratory of Cellular Immunotherapy,
Novosibirsk
Russian FederationO. Yu. Leplina
Federal Budget Institution of Science «Research Institute of Fundamental and Clinical Immunology»
Email: fake@neicon.ru
PhD, MD (Medicine), Leading Research Associate, Laboratory of Cellular Immunotherapy,
Novosibirsk
Russian FederationE. V. Batorov
Federal Budget Institution of Science «Research Institute of Fundamental and Clinical Immunology»
Email: fake@neicon.ru
PhD (Medicine), Research Associate, Laboratory of Cellular Immunotherapy,
Novosibirsk
Russian FederationA. A. Ostanin
Federal Budget Institution of Science «Research Institute of Fundamental and Clinical Immunology»
Email: fake@neicon.ru
PhD, MD, Professor (Medicine), Main Research Associate, Laboratory of Cellular Immunotherapy,
Novosibirsk
Russian FederationN. M. Pasman
Novosibirsk National Research State University
Email: fake@neicon.ru
PhD, MD, Professor (Medicine), Head of Department of Obstetrics and Gynecology,
Novosibirsk
Russian FederationReferences
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