Email this article EFFECTS OF ACUTE COLD STESS ON IFNγ AND IL-12 PRODUCTION BY MICE SPLENOCYTES
- Authors: Sharav’eva I.L.1, Tendryakova S.P.1,2
-
Affiliations:
- Institute of Ecology and Genetics of Microorganisms, UB RAS
- Perm State University
- Issue: Vol 22, No 2-2 (2019)
- Pages: 972-974
- Section: ORIGINAL ARTICLES
- URL: https://rusimmun.ru/jour/article/view/427
- DOI: https://doi.org/10.31857/S102872210006500-5
- ID: 427
Cite item
Full Text
Abstract
The effect of cold stress on the production of reactive oxygen species (ROS) and IFN-γ and IL-12 was studied 6 hours after the end of stress. It was established that acute cold stress (–20 °C for 60 min) led to increased spontaneous and zymosan-stimulated production of ROS by mouse peritoneal cavity cells 6 hours after the end of stress exposure. In similar experimental conditions, the levels of interferon-γ in spontaneous splenocytes mice increased, while in stimulated mice decreased.
Keywords
About the authors
I. L. Sharav’eva
Institute of Ecology and Genetics of Microorganisms, UB RAS
Author for correspondence.
Email: irin.sh@gmail.com
PhD, recercher of the laboratory of biochemistry of development of microorganisms,
Perm
Russian FederationS. P. Tendryakova
Institute of Ecology and Genetics of Microorganisms, UB RAS;Perm State University
Email: fake@neicon.ru
PhD, senior recercher of the laboratory of ecological immunology;
docent Department of microbiology and immunology,
Perm
Russian FederationReferences
- DhaBhar F. S. The short-term stress response – Mother nature’s mechanism for enhancing protection and performance under conditions of threat, challenge, and opportunity. Frontiers in Neuroendocrinology. 2018, 49, 175–192.
- Sesti-Costa R., Ignacchiti M. D., Chedraoui-Silva S. Marchi L. F., Mantovani B. Chronic cold stress in mice induces a regulatory phenotype in macrophages: correlation with increased 11β-hydroxysteroid dehydrogenase expression. Brain Behav Immun. 2012, 26, 50–60.
- Zhu G. F., Chancellor-Freeland C., Berman A. S., Leeman S. E., Beller D. I., Black P. H. Endogenous substance P mediates cold water stress-induced increase in interleukin-6 secretion from peritoneal macrophages. 1996, J. Neurosci., 16, 3745–3752.
- Гейн С. В., Шаравьева И. Л. Влияние холодового стресса на функциональную активность перитонеальных макрофагов мыши в условиях блокады опиатных рецепторов. 2016, Российский физиологический журнал им. И. М. Сеченова, 2, 188–194.
Supplementary files
СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).