OBTAINING AND PRECLINICAL STUDIES OF RECOMBINANT PSEUDOMONAS VACCINE

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Authors: Mikhailova N.A.¹, Kaloshin A.A.¹, Zimina E.M.¹, Kalinichenko E.O.¹, Soldatenkova A.V.¹, Plekhanova N.G.², Victorov L.V.²
Affiliations:
1. The Mechnikov Research Institute for Vaccines and Sera
2. The Volgograd Antiplague Research Institute of Rospotrebnadzor
Issue: Vol 22, No 2-2 (2019)
Pages: 1015-1017
Section: ORIGINAL ARTICLES
Submitted: 15.08.2020
Accepted: 15.08.2020
Published: 15.07.2019
URL: https://rusimmun.ru/jour/article/view/461
DOI: https://doi.org/10.31857/S102872210006487-0
ID: 461

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Abstract
About the authors
References
Supplementary files
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Abstract

Three experimental lots of Recombinant Pseudomonas Vaccine (RPV) consisting a complex of the recombinant outer membrane protein F (OprF) and the recombinant toxoid that were sorbed on aluminum hydroxide have been obtained. During preclinical studies, we confi rmed the immunogenicity of the vaccine that had not pyrogenicity, acute and chronic toxicity, allergenicity and immunotoxicity.

Keywords

Pseudomonas aeruginosa, Recombinant Pseudomonas Vaccine (RPV), Outer Membrane Protein F (OprF), Toxoid

About the authors

N. A. Mikhailova

The Mechnikov Research Institute for Vaccines and Sera

Author for correspondence.
Email: alex-k-1973@yandex.ru

D. Sc., Head of the Laboratory of the protective antigens,

Moscow

Russian Federation

A. A. Kaloshin

The Mechnikov Research Institute for Vaccines and Sera

Email: fake@neicon.ru

PhD, Leading researcher of Laboratory of the protective antigens,

Moscow

Russian Federation

E. M. Zimina

The Mechnikov Research Institute for Vaccines and Sera

Email: fake@neicon.ru

Researcher of Laboratory of the protective antigens,

Moscow

Russian Federation

E. O. Kalinichenko

The Mechnikov Research Institute for Vaccines and Sera

Email: fake@neicon.ru

Aspirant,

Moscow

Russian Federation

A. V. Soldatenkova

The Mechnikov Research Institute for Vaccines and Sera

Email: fake@neicon.ru

PhD, Senior research of Laboratory of the protective antigens,

Moscow

Russian Federation

N. G. Plekhanova

The Volgograd Antiplague Research Institute of Rospotrebnadzor

Email: fake@neicon.ru

PhD, Head of the Laboratory of the experimental biomodels,

Volgograd

Russian Federation

L. V. Victorov

The Volgograd Antiplague Research Institute of Rospotrebnadzor

Email: fake@neicon.ru

D. Sc., Head of the temporary creative team,

Volgograd

Russian Federation

References

Лазарева А. В., Чеботарь И. В., Крыжановская О. А., Чеботарь В. И., Маянский Н. А. Pseudomonas aeruginosa патогенность, патогенез и патология. Клиническая микробиология и антимикробная химиотерапия. 2015, 17(3):170–186.
Doring G. and Pier G. B. Vaccines and immunotherapy against Pseudomonas aeruginosa. Vaccine, 2008, 6(8):1011–1024.
Калошин А. А., Солдатенкова А. В., Леонова Е. И., Михайлова Н. А. Получение рекомбинантного гибридного белка OprF-aTox Pseudomonas aeruginosa и исследование его протективных свойств. Российский иммунологический журнал. 2015, 9(2): 490–491.

Supplementary files

Supplementary Files

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Copyright (c) 2019 Mikhailova N.A., Kaloshin A.A., Zimina E.M., Kalinichenko E.O., Soldatenkova A.V., Plekhanova N.G., Victorov L.V.

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This work is licensed under a Creative Commons Attribution 4.0 International License.

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