EXPRESSION OF IMMUNE RESPONSE GENES IN CHRONICALLY IRRADIATED PERSONS AT LATE PERIOD AFTER EXPOSURE

Cover Page


Cite item

Full Text

Abstract

At late period after exposure a decrease in the level of NF-kB1gene expression and an increase in the level of PAD4 gene expressionwere registered in exposed persons. Considering the dependence of some immunity parameters on the levels of NF-kB1 and PAD4geneexpression, it can be assumed that changes in the immunity of exposed personsin the remote period can be mediated by changes in transcriptional activity of genes.

About the authors

A. A. Akleyev

Urals Research Center for Radiation Medicine of the FMBA of Russia;
Southern-Urals State Medical University of the RF Ministry of Public Health

Author for correspondence.
Email: andrey.akleev@yandex.ru

Senior researcher of Molecular-cell Radiobiology Laboratory;

M.D., PhD, Associate Professor of the Department of Microbiology, Virology, Immunology and Clinical Laboratory Diagnostics,

Chelyabinsk

Russian Federation

V. S. Nikiforov

Urals Research Center for Radiation Medicine of the FMBA of Russia;
Chelyabinsk State University

Email: fake@neicon.ru

Junior researcher of Molecular-cell Radiobiology Laboratory;

Postgraduate student of the Department of Radiation Biology, 

Chelyabinsk

Russian Federation

E. A. Blinova

Urals Research Center for Radiation Medicine of the FMBA of Russia;
Chelyabinsk State University

Email: fake@neicon.ru

PhD, Head of Molecular-cell Radiobiology Laborator;

Associate Professor of the Department of Radiation Biology,

Chelyabinsk

Russian Federation

I. I. Dolgushin

Southern-Urals State Medical University of the RF Ministry of Public Health

Email: fake@neicon.ru

M.D., Professor, Academician of the Russian Academy of Sciences, Head of Microbiology, Virology, Immunology and Clinical Laboratory Diagnostics Department,

Chelyabinsk

Russian Federation

References

  1. Шуленина Л. В., Ушенкова Л. Н., Ледин Е. В., Шагирова Ж. М., Раева Н. Ф., Засухина Г. Д., Михайлов В. Ф. Экспрессия генов Р53, NPM1, Кras, с-Мус, P14АRF в крови онкологических больных до и после лучевой терапии. Радиационная биология. Радиоэкология. 2012, 52 (6), 572–581.
  2. Database of metabolic pathways KEGG PATHWAY Database. 2018. URL: http://www.genome.jp/kegg/pathway.html.

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c) 2019 Akleyev A.A., Nikiforov V.S., Blinova E.A., Dolgushin I.I.

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: серия ПИ № 77 - 11525 от 04.01.2002.


This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies