ASSOCIATION OF GENE POLYMORPHISMS WITH SOME INDICATORS OF ADAPTIVE IMMUNITY IN CHRONICALLY EXPOSED PERSONS

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Abstract

Associations between polymorphic sites rs2239815 of gene MAPK8, rs1053023 of gene STAT3, rs4143094 of gene GATA3, rs28362491 of gene NF-kB1 with the absolute and relative number of CD19+ lymphocytes, CD3+CD4+ lymphocytes and with the absolute content of CD3+ and CD3+CD8+ lymphocytes were registeredin exposed persons. 

About the authors

E. A. Blinova

Urals Research Center for Radiation Medicine of the FMBA of Russia;
Chelyabinsk State University

Author for correspondence.
Email: fake@neicon.ru

PhD, Head of Molecular-cell Radiobiology Laboratory;

Associate Professor of the Department of Radiation Biology,

Chelyabinsk

Russian Federation

A. A. Akleyev

Urals Research Center for Radiation Medicine of the FMBA of Russia;
Southern-Urals State Medical University of the RF Ministry of Public Health

Email: andrey.akleev@yandex.ru

Senior researcher of Molecular-cell Radiobiology Laboratory;

M.D., PhD, Associate Professor of the Department of Microbiology, Virology, Immunology and Clinical Laboratory Diagnostics,

Chelyabinsk

Russian Federation

A. I. Kotikova

Urals Research Center for Radiation Medicine of the FMBA of Russia

Email: fake@neicon.ru

senior laboratory assistantof Molecular-cell Radiobiology Laboratory, 

Chelyabinsk

Russian Federation

M. A. Yanishevskaya

Chelyabinsk State University

Email: fake@neicon.ru

undergraduate of the Department of Radiation Biology,

Chelyabinsk

Russian Federation

References

  1. Visscher P. M., Brown M. A., McCarthy M.I., Yang J. Five years of GWAS discovery. Am J. Hum. Genet. 2012, 13, 90 (1), 7–24.
  2. Подколодный Н. Л., Афонников Д. А., Васькин Ю. Ю., Брызгалов Л. О., Иванисенко В. А., Деменков П. С., Пономаренко М. П., Рассказов Д. А., Гунбин К. В., Процук И. В., Шутов И. Ю., Леонтьев П. Н., Фурсов М. Ю., Бондарь Н. П., Антонцева Е. В., Меркулова Т. И., Колчанов Н. А. Программный комплекс SNP-MED для анализа влияния однонуклеотидных полиморфизмов на функцию генов, связанных с развитием социально значимых заболеваний. Вавиловский журнал генетики и селекции. 2013, 17, 4/1, 577–588.
  3. Database of metabolic pathways KEGG PATHWAY Database. 2018. URL: http://www.genome.jp/kegg/pathway.html.

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Copyright (c) 2019 Blinova E.A., Akleyev A.A., Kotikova A.I., Yanishevskaya M.A.

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